Micro-channel internal pressure testing method based on micro-bubbles

Abstract

The invention provides a micro-channel internal pressure testing method based on micro-bubbles. The method comprises the following steps of injecting the insoluble micro-bubbles into micro-channel liquid under a constant-temperature environment, wherein the volume of the micro-bubbles changes along with the change of the micro-channel internal pressure; photographing micro-bubble images at different positions of a channel in combination with a microscope and a high-speed camera, calculating the volume and the relative volume change of the micro-bubbles, or directly measuring the volume of themicro-bubbles at different positions of a micro-channel by means of ultrasonic waves, rays and the like to obtain the relative volume change of the micro-bubbles; based on a gas state equation, usingthe relative volume change of the micro-bubbles to calculate the relative pressure change at different positions in the micro-channel; connecting a micro-channel outlet to the outside atmosphere to determine a pressure value at the outlet; and calculating the pressure at different positions in the micro-channel or a pressure difference between different positions through the relative pressure change at different positions in the micro-channel and the pressure value at the micro-channel outlet. The micro-channel internal pressure testing method based on the micro-bubbles provided by the invention is convenient to measure, simple to operate, high in precision and free of damage to the micro-channel structure, and has an important application value in the fields of biomedicine, micro chip integration and the like.

Description

technical field [0001] The invention relates to a pressure testing method, in particular to a micro-bubble-based microchannel internal pressure testing method. Background technique [0002] Pressure measurement in micro-scale channels has important application value in biomedicine, microchip integration and other fields. For example, there are a large number of capillaries distributed in the human body, the diameters of which are often on the order of microns, and blood flows in these micro-scale channels. By accurately measuring the pressure distribution in capillaries, it is possible to study the blood flow in capillaries during thrombus formation and development, which helps to reveal the process and mechanism of thrombus formation and development in capillaries. In addition, the pressure drop in the microchannel is an important factor to be considered in the integration process of the microfluidic chip. Accurate measurement of the pressure in each microchannel on the m...

AI Technical Summary

Problems solved by technology

The traditional differential pressure gauge pressure measurement method is to measure the pressure by connecting a differential pressure gauge at the entrance and exit of the microchannel. The introduction of a new hole will cause additional local resistance loss, thereby introducing new measurement errors.

In addition, the new openings are irreversibly destructive to the original microchannels

The pressure-sensitive coating method needs to arrange complex pressure-sensitive materials in the microchannel, and the optical film method and the pressure microfilm sensor method need to arrange special pressure test components in the microchannel, and the processing and operation are relatively complicated.

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