A method for improving the protective effect of creatine on excitotoxicity

A technology of neurotoxicity and excitability, applied in the field of biomedicine, can solve the problems of not mentioning Cr, limited therapeutic effect, ignoring the catalytic function of CK, etc., and achieve the effect of improving the protective effect
CN109758445BActive Publication Date: 2021-07-02็Ž‹้“้น
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
็Ž‹้“้น
Publication Date
2021-07-02

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Abstract

The invention discloses a method for improving the protective effect of creatine on excitatory neurotoxicity, establishes an excitotoxic model of SHโ€‘SY5Y cells treated with exogenous nitric oxide donor GSNO, and uses the model to prove that simple muscle Acid factor has a protective effect on neuroexcitotoxicity, but the effect is limited. In the SHโ€‘SY5Y cell model treated with GSNO, the two neural creatine kinases CKBB and CKMT were nitrosylated, and the protein content and enzyme activity of the two were significantly reduced after modification; overexpression denitrosylation The modification enzyme GSNOR can significantly reduce the nitrosylation modification of CKBB and CKMT, and can significantly restore the content and activity of CKBB and CKMT. The present invention can significantly enhance the protective effect of creatine on excitotoxicity in combination with the denitrosylation modification scheme of neural creatine kinase.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and relates to a method for improving the protective effect of creatine on excitatory neurotoxicity, in particular to a denitrosylation modification method of neural creatine kinase (CKBB and CKMT) in enhancing creatine Drug application in neuroprotective effect. Background technique

[0002] Neurodegenerative diseases are a group of neurological diseases that result in progressive functional variation and death of nerve cells, leading to abnormal behavior and dysfunction of patients, and premature death, including Alzheimer's disease (AD), Parkinson's disease disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), etc. Excitotoxicity is a common pathway leading to late neuronal death in the pathogenesis of neurodegenerative diseases. Among them, energy depletion caused by processes such as mitochondrial respiratory chain inhibition, glycolysis inhibition, and energy c...

Claims

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