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Application of halofuginone to preparation of medicines for preventing foot and mouth disease virus infection

A technology for foot-and-mouth disease virus and halofuginone, which is applied in the directions of antiviral agents, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as inability to provide protection for animals

Active Publication Date: 2019-05-24
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, vaccine immunization is the main means of preventing and controlling foot-and-mouth disease. However, there is an "immunity window period" in the use of vaccines, that is, it cannot provide protection to animals within 7 days.

Method used

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  • Application of halofuginone to preparation of medicines for preventing foot and mouth disease virus infection
  • Application of halofuginone to preparation of medicines for preventing foot and mouth disease virus infection
  • Application of halofuginone to preparation of medicines for preventing foot and mouth disease virus infection

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Experimental materials

[0022] 1.1 Cells, viruses and drugs

[0023] IBRS-2 cells were preserved by our research group; FMDV (O / MY98 / BY / 2010 and A / GDMM / CHA / 2013) were preserved and provided by the National Foot-and-Mouth Disease Reference Laboratory; Halofuginone was purchased from MCE Company and prepared in DMSO.

[0024] 1.2 Reagents

[0025] DMEM, fetal bovine serum FBS, and trypsin medium were purchased from Gibco; MTS detection kits were purchased from Abcam; TRIZOL was purchased from Invitrogen; SYBR Premix Ex TaqⅡ kits were purchased from Treasure Bioengineering (Dalian) Co., Ltd.; RIPA The lysate, BCA protein quantification kit, SDS-PAGE gel preparation kit, and ECL were purchased from Beyontian; BSA and PVDF membranes were purchased from BioRad; Tween-20 was purchased from Shanghai Sangon Bioengineering Company; Triton X -100. DMSO was purchased from Sigma Company; mouse anti-β-actin polyclonal antibody, HRP-labeled anti-rabbit or anti-mouse IgG antibody...

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Abstract

The invention belongs to the technical field of veterinary medicines and relates to application of halofuginone to preparation of medicines for preventing foot and mouth disease virus infection. The efficient, safe and quality-controllable medicines resistant to foot and mouth disease viruses are provided for further control of spread of the foot-and-mouth disease.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to the application of hemosanone in the preparation of drugs for preventing foot-and-mouth disease virus infection. Background technique [0002] Foot-and-mouth disease virus is a non-enveloped single-stranded positive-sense RNA virus belonging to the Picornaviridae family. It has been found that the virus includes 7 serotypes including A, O, C, Asian I, and South African I, II, and III, and each serotype is divided into multiple subtypes. The foot-and-mouth disease caused by this virus mainly infects cloven-hoofed animals such as pigs and cattle, and often forms blisters in the mouth, nose, hooves and other parts, accompanied by clinical symptoms such as fever and walking. Foot-and-mouth disease has many transmission routes, wide epidemic range and strong infectivity. Currently, frequent outbreaks in many countries have seriously threatened the development of global anima...

Claims

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Application Information

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IPC IPC(8): A61K31/517A61P31/14
Inventor 常惠芸李世芳龚美娇邵军军常艳燕张永光
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI