Particle capture structure, particle capture chip and particle capture method
A particle capture and substrate technology, applied in chemical instruments and methods, laboratory containers, instruments, etc., can solve the problems of complex structure and cost increase, and achieve the effect of expanding application range, low cost and simple structure
Active Publication Date: 2021-12-03
BOE TECH GRP CO LTD +1
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Problems solved by technology
[0004] Embodiments of the present invention provide a particle capture structure, a particle capture chip, and a particle capture method, which can solve the problems of complex structures and increased costs of existing particle capture structures due to the need for additional optical systems
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[0029] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
[0030] Dielectrophoresis (DEP) is a technology that can quickly and efficiently capture and aggregate tiny biological particles such as cells and proteins. The force that moves particles in DEP technology is called DEP force, and its expression is as follows:
[0031]
[0032] In the formula is the complex permittivity (where ε, σ and ω are the permittivity, conductivity and angular frequency, respectively), the subscripts p and m represent the particle a...
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Abstract
Embodiments of the present invention provide a particle capture structure, a particle capture chip, and a particle capture method, which relate to the field of digital microfluidics technology and can solve the problems of complex structure and increased cost of the particle capture structure due to the need for an additional optical system. The particle trapping structure includes a lower substrate on which a plurality of light-emitting units and a first conductive layer covering the plurality of light-emitting units are arranged, and a photoconductive layer is arranged on the first conductive layer; when the photoconductive layer is irradiated by light , the conductivity of the illuminated area increases; the upper substrate, the upper substrate and the lower substrate are combined, the surface of the upper substrate away from the lower substrate is provided with a liquid injection port and a liquid outlet, and the surface of the upper substrate close to the lower substrate is provided with a groove , the liquid injection port and the liquid outlet are connected to the groove, and the bottom of the groove is provided with a second conductive layer; the liquid injection port, the groove and the liquid outlet form the liquid flow channel to be tested, and the liquid flow channel to be tested is on the lower substrate The projection on covers multiple light emitting units. The present invention is used for particle capture and transport.
Description
technical field [0001] The invention relates to the technical field of digital microfluidics, in particular to a particle capture structure, a particle capture chip and a particle capture method. Background technique [0002] Micro-fluidics technology is a technology that precisely controls and manipulates micro-scale fluids. It can integrate the basic operating units such as sample preparation, reaction, separation, and detection in the process of biochemical analysis into a micron-scale chip. The whole process of analysis is completed automatically. Microfluidic technology has the advantages of less sample consumption, fast detection speed, easy operation, multi-functional integration, small size and portability, and has great application potential in the fields of biology, chemistry, and medicine. Dielectrophoresis technology (Dielectrophoresis, DEP) is a kind of microfluidic technology, which can quickly and efficiently realize the capture and aggregation of tiny biolog...
Claims
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IPC IPC(8): B01L3/00G01N35/00
Inventor 肖月磊崔皓辰蔡佩芝
Owner BOE TECH GRP CO LTD