Method for preparing 3-aminobutyric acid by using poly-3-hydroxybutyrate

A technology of hydroxybutyrate and aminobutyric acid, which is applied in chemical instruments and methods, preparation of cyanide reaction, preparation of organic compounds, etc., can solve the problem of high cost, limitation of industrial production and application of 3-aminobutyric acid, and production scale Small problems, to achieve the effect of simple process

Active Publication Date: 2019-06-04
DONGGUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the preparation of 3-aminobutyric acid mainly uses crotonic acid, a high-value industrial product, as a raw material. The production s

Method used

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  • Method for preparing 3-aminobutyric acid by using poly-3-hydroxybutyrate

Examples

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Effect test

Embodiment 1

[0017] A method for preparing 3-aminobutyric acid with poly 3-hydroxybutyrate, the method is as follows:

[0018] (1) Put 1 g of poly-3-hydroxybutyrate and 30 ml of ammonia water (28% concentration) into the reactor, and seal the reactor;

[0019] (2) Turn on the stirrer to make it rotate at 500 rpm, and raise the temperature to 160° C. at a rate of 6 degrees per minute, and keep it at 160° C. for 12 hours. After the reaction was complete, it was cooled to room temperature, and 1.2 g of 3-aminobutyric acid was obtained through quantitative analysis by high performance liquid chromatography. Based on the initial mass of poly-3-hydroxybutyrate, the yield of 3-aminobutyric acid obtained was 120%, and the selectivity of 3-aminobutyric acid was 100%.

Embodiment 2

[0021] A method for preparing 3-aminobutyric acid with poly 3-hydroxybutyrate, the method is as follows:

[0022] (1) Put 1 g of poly-3-hydroxybutyrate and 30 ml of ammonia water (28% concentration) into the reactor, and seal the reactor;

[0023] (2) Turn on the stirrer to make it rotate at 500 rpm, and raise the temperature to 180° C. at a rate of 6 degrees per minute, and keep it at 180° C. for 16 hours. After the reaction was complete, it was cooled to room temperature, and 1.18 g of 3-aminobutyric acid was obtained through quantitative analysis by high performance liquid chromatography. Based on the initial mass of poly-3-hydroxybutyrate, the yield of 3-aminobutyric acid obtained was 118%.

Embodiment 3

[0025] A method for preparing 3-aminobutyric acid with poly 3-hydroxybutyrate, the method is as follows:

[0026] (1) Put 1 g of poly-3-hydroxybutyrate and 30 ml of ammonia water (28% concentration) into the reactor, and seal the reactor;

[0027] (2) Turn on the stirrer to make it rotate at 500 rpm, and raise the temperature to 120° C. at a rate of 6 degrees per minute, and keep it at 120° C. for 24 hours. After the reaction was complete, it was cooled to room temperature, and 0.91 g of 3-aminobutyric acid was obtained through quantitative analysis by high performance liquid chromatography. Based on the initial mass of poly-3-hydroxybutyrate, the yield of 3-aminobutyric acid obtained was 91%.

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Abstract

The invention provides a method for preparing 3-aminobutyric acid by using poly-3-hydroxybutyrate, and the method comprises the following steps: (1) adding the poly-3-hydroxybutyrate and ammonia waterinto a reaction container, and sealing the reaction container; and (2) opening a stirrer, heating the reaction container, and after the reaction is finished, cooling to room temperature to obtain the3-aminobutyric acid. The method disclosed by the invention is used for preparing the 3-aminobutyric acid by using the poly-3-hydroxybutyrate, the mass yield of the obtained 3-aminobutyric acid is 120% based on the content of the poly-3-hydroxybutyrate, namely, the yield reaches 100% of the theoretical yield. The adopted process is very simple, the reaction raw materials are the poly-3-hydroxybutyrate and the ammonia water, no catalyst or other additives are needed, the selectivity of the 3-aminobutyric acid can reach 100%, and the method has an industrial prospect.

Description

technical field [0001] The invention relates to the application field of poly 3-hydroxybutyrate, in particular to a method for preparing 3-aminobutyric acid from poly 3-hydroxybutyrate. Background technique [0002] 3-aminobutyric acid is an important high-value drug. A typical use of 3-aminobutyric acid is that it can significantly improve the disease resistance of plants and also increase the resistance of plants to abiotic stress. In addition, R-3-aminobutyric acid can be reduced to 3-aminobutanol, and 3-aminobutanol is a key intermediate for the treatment of AIDS drug dolutegravir. However, 3-aminobutyric acid is a non-protein source amino acid that does not exist in animal and plant proteins. Therefore, it is necessary to artificially synthesize 3-aminobutyric acid with other chemicals or raw materials. However, at present, the preparation of 3-aminobutyric acid mainly uses crotonic acid, a high-value industrial product, as a raw material. The production scale of cro...

Claims

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Application Information

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IPC IPC(8): C07C227/08C07C229/08
Inventor 康世民彭喆喆陈相晓程文贵李荣全黎俊杰
Owner DONGGUAN UNIV OF TECH
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