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Method for rapid identification and composition analysis of drugs

A component analysis and drug technology, applied in the field of drug rapid identification and component analysis, can solve the problems of complex operation, inability to meet rapid detection, long sample analysis time, etc. Effect

Inactive Publication Date: 2019-06-04
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The traditional detection methods of active ingredients in opium are mainly chromatographic techniques, chromatography-mass spectrometry, etc., all of which require complex sample pretreatment, not only complicated operations, but also a long time required for sample analysis; and due to the limitations of instruments , the detection process can usually only be completed in the laboratory, which cannot meet the requirements of on-site rapid detection

Method used

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  • Method for rapid identification and composition analysis of drugs
  • Method for rapid identification and composition analysis of drugs
  • Method for rapid identification and composition analysis of drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] figure 1 A schematic diagram of the specific operation flow of a method for analyzing components in solid paste drugs is provided. The operation is mainly divided into four main steps, which are sample extraction, rinsing, sample application, mass spectrometry detection and result analysis. The peak of m / z=286 in the spectrum of direct mass spectrometry is the molecular ion peak of morphine [M+H] + , the peak of m / z=300 is the molecular ion peak [M+H] of codeine + , m / z=312 is the molecular ion peak of thebaine [M+H] + , the peak at m / z=340 is the molecular ion peak of papaverine [M+H] + , the peak of m / z=414 is the molecular ion peak of narcotine [M+H] + , as shown in Table 1, the identification of the main mass spectrum peaks in the full-spectrum scanning mass spectrum.

[0045] image 3 Shown in the secondary mass spectrometry spectrogram m / z=201 is the characteristic fragment ion peak of morphine, m / z=215 is the characteristic fragment ion peak of codeine, m / z=2...

Embodiment 2

[0047] Figure 4 In the middle is the primary and secondary tandem mass spectrometry results of the mass spectrometry of the pink flake suspected drugs seized at the Yunnan scene using our rapid analysis method. m / z=150 is the mass spectrum peak of methamphetamine, m / z=194 is the molecular ion peak of caffeine, and m / z=119 is the [M-CH 5 N] + Fragment ion peaks.

Embodiment 3

[0049] Figure 5 In this paper, we used our rapid analysis method to analyze the mass spectrometry results of primary and secondary tandem mass spectrometry of white drugs seized in Yunnan on-site in the case of human drug possession. m / z is the mass spectrum peak of heroin, m / z=342 is the molecular ion peak of acetylcodeine, m=328 is the fragment ion peak of heroin [M-C 2 h 2 O] + .

[0050] Table 1 Main mass spectrum peak identification

[0051]

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Abstract

The invention relates to a method for rapid identification and composition analysis of drugs. The method comprises the steps of: taking a cotton swab dipped in methanol as an extraction medium, and swabbing the surface of a solid by means of the cotton swab to extract main components therein; then inserting the cotton swab into a reagent bottle containing methanol for simple washing and shaking, so as to dilute the amount of drugs dipped on the cotton swab, or directly painting on a sample injection cloth by using the cotton swab without dilution; and finally, using a portable ion trap mass spectrometer as a detection instrument, and identifying the suspected drug solid as opium through direction mass spectrometry and tandem mass spectrometry. The method is suitable for the rapid detectionof drug compositions in opium, and is suitable for the rapid detection of compositions in drugs of other types such as methamphetamine, heroin and marijuana. The method has the advantages that the sample pretreatment time is less than 5 min, the mass spectrometric detection time is less than 2 s, and the detection limits of five kinds of drug samples are all less than 10 ng, thereby greatly contributing to the on-site investigation, seizing and identification of drugs.

Description

technical field [0001] The invention discloses a method for identifying and rapidly analyzing components in suspected solid drugs. In this method, a cotton swab dipped in methanol is used as the extraction medium, and the main components are extracted by wiping the cotton swab on the surface of the solid, and then the cotton swab can be inserted into a reagent bottle containing methanol for simple rinsing and shaking to dilute the concentration on the cotton swab. The amount of some drugs, or directly smear it on the sampling cloth with a cotton swab without dilution. Finally, using a portable ion trap mass spectrometer as a detection instrument, through direct mass spectrometry and tandem mass spectrometry, the suspected drug solid was identified as opium. The method is not only suitable for the rapid detection of drug components in opium, but also suitable for the rapid detection of components in other types of drugs such as methamphetamine, heroin, marijuana and other drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62
Inventor 侯可勇王伟民王爽李虹刑豫明李海洋
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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