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A kind of method for preparing florfenicol

A technology of florfenicol and reaction kettle, which is applied in the field of preparation of florfenicol, can solve the problems of poor solubility, affecting bioavailability, difficulty in obtaining ultrafine powder products, etc., and achieves the effect of obvious crushing effect

Active Publication Date: 2021-01-05
京山瑞生制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Not only has no potential aplastic anemia effect, but also has no adverse effects such as teratogenic, carcinogenic and mutagenic
[0005] Compared with similar antibiotics, although florfenicol has excellent performance, its solubility in water is too poor, which affects its bioavailability
At present, the preparation of florfenicol ultrafine powder has become the development trend of the industry, but florfenicol products are easy to crystallize, and it is very difficult to obtain ultrafine powder products
The ultrafine pulverization equipment common in the industry is not only inefficient, but also the particle size of the obtained micropowder is generally larger than 20 microns

Method used

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  • A kind of method for preparing florfenicol
  • A kind of method for preparing florfenicol

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) In the reaction kettle, add the solvent dimethylformamide (DMF), dissolve the original powder of Florfenicol in DMF, and prepare the DMF solution of Florfenicol, wherein the concentration of Florfenicol is 50mg / ml.

[0027] (2) In another reaction kettle 5, add an aqueous aluminum sulfate solution prepared by pure water through the material feed port 6, wherein the salt concentration is 10%.

[0028] (3) Turn on the strong agitation of the aluminum-containing salt solution, control the temperature at -10°C through the heat exchanger 2, and transfer the DMF solution of Florfenicol through the high-pressure delivery pump 3 to the reactor based on the reactor 5. The jet mixer 1 of the Venturi effect is sprayed into the aluminum-containing brine solution, and the jet mixer 1 of the reactor is immersed in the liquid phase of the reaction vessel 5 . Continue vigorous stirring for 60 min. A suspension of florfenicol was obtained. Wherein the volume ratio of the aluminu...

Embodiment 2

[0031] (1) In the reactor, add solvent dimethylformamide (DMF), dissolve the original powder of Florfenicol in DMF, and prepare the DMF solution of Florfenicol, wherein the concentration of Florfenicol is 100mg / ml.

[0032] (2) In another reactor 5, add an aqueous alum solution prepared with pure water through the material feed port 6, wherein the salt concentration is 1%.

[0033] (3) Turn on the strong stirring of the aluminum-containing salt solution, control the temperature at 10°C through the heat exchanger 2, and transfer the DMF solution of Florfenicol through the high-pressure delivery pump 3 through the Venturi-based The jet mixer 1 of the Li effect is sprayed into the aluminum-containing salt solution, and the jet mixer 1 of the reactor is immersed in the liquid phase of the reactor. Continue vigorous stirring for 30 min. A suspension of florfenicol was obtained. Wherein the volume ratio of the aluminum-containing salt solution to the DMF solution of Florfenicol ...

Embodiment 3

[0036] (1) In the reaction kettle, add the solvent dimethylformamide (DMF), dissolve the former powder of Florfenicol in DMF, and prepare the DMF solution of Florfenicol, wherein the concentration of Florfenicol is 75mg / ml.

[0037] (2) In another reaction kettle 5, an aqueous aluminum sulfate solution prepared with pure water is added through the material feed port 6, wherein the salt concentration is 5%.

[0038] (3) Turn on the strong agitation of the aluminum-containing salt solution, control the temperature at 0°C through the heat exchanger 2, and transfer the DMF solution of Florfenicol through the high-pressure delivery pump 3 through the Venturi-based The jet mixer 1 of the Li effect is sprayed into the aluminum-containing salt solution, and the jet mixer 1 of the reactor is immersed in the liquid phase of the reactor. Continue vigorous stirring for 60 min. A suspension of florfenicol was obtained. Wherein the volume ratio of the aluminum-containing salt solution t...

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Abstract

The invention discloses a method for preparing florfenicol. The method comprises the following steps: adding a solvent dimethylformamide (DMF) into a reaction kettle, dissolving florfenicol raw powderin the DMF to prepare a DMF solution of florfenicol, preparing an aqueous solution containing an aluminum salt in another reactor by using pure water, intensively stirring the aqueous solution containing the aluminum salt, controlling the temperature of the solution at a certain value, and spraying the DMF solution of florfenicol into the aqueous solution containing the aluminum salt by a high-pressure transfer pump. The adopted aqueous solution containing the salt especially the aluminum salt has a particularly excellent ultra-micro effect, and the method can not only effectively control a fluid to flow in a fully developed high-speed turbulent flow state, so the realization of the ultra-micro effect is benefited; and a jet mixer introduces a large amount of air to form full mixing of air and the liquid, so liquid drops are extremely significantly broken, and a cavitation effect is formed, thereby formation of ultrafine nanocrystals is benefited.

Description

technical field [0001] The invention belongs to the technical field of organic chemistry, and in particular relates to a method for preparing florfenicol. Background technique [0002] Florfenicol, also known as florfenicol, is a chloramphenicol broad-spectrum antibiotic developed in the late 1990s. The molecular formula is and the structural formula is as follows. [0003] [0004] It has the characteristics of broad antibacterial spectrum, no potential aplastic anemia effect, and safe application, and is widely used to reduce bacterial infections in aquatic animals and livestock and poultry. Chloramphenicol will cause severe aplastic anemia and other adverse reactions after administration in animals, so some countries have banned the use of chloramphenicol, especially for animals used in food production. Experimental studies have shown that the reason why chloramphenicol causes adverse reactions is that its structure contains a para-nitro group, which is the main caus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C315/06C07C317/32
Inventor 周国朝张治国钟旭辉李晓明
Owner 京山瑞生制药有限公司
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