A kind of preparation method of florfenicol superfine powder

Abstract

The invention discloses a preparation method of florfenicol superfine powder, which comprises adding solvent acetone into a reaction kettle, dissolving the original florfenicol powder in acetone, preparing florfenicol acetone solution, and preparing florfenicol acetone solution in another In a reaction kettle, a saline solution is prepared, and the saline solution is started to stir vigorously, and the acetone solution of florfenicol is quickly pumped into the saline solution through a high-pressure delivery pump. The present invention adopts a saline solution, especially a high-concentration saline solution close to a saturated state, which has a particularly excellent ultrafine effect, and at the same time, the acetone solution of Florfenicol is quickly pumped into the liquid surface of the saline solution through a high-pressure delivery pump Below, the fluid flow can be effectively controlled to be in a fully developed high-speed turbulent state, which is conducive to the realization of ultra-fine effects.

Description

technical field [0001] The invention belongs to the technical field of organic chemistry, and in particular relates to a preparation method of florfenicol superfine powder. Background technique [0002] Florfenicol (Florfenicol) Chinese name: fluprofen; [0003] It was first launched in Japan in 1990. In 1993, Norway approved the drug to treat salmon furunculosis. In 1995, France, the United Kingdom, Austria, Mexico and Spain approved it to treat bovine respiratory system bacterial diseases. In Japan and Mexico, it is also approved to be used as a feed additive for pigs to prevent and treat bacterial diseases in pigs. Our country has passed the approval of this drug at present. [0004] Florfenicol has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, safety and high efficiency, and has no potential aplastic anemia, teratogenic, carcinogenic and mutagenic effects, especially chloramphenicol has serious It is forbidden to b...

AI Technical Summary

Problems solved by technology

And injection is difficult to be applied on a large scale in large-scale farms due to inconvenient application.

Moreover, most of the injections are prepared with organic solvents such as dimethylformamide and propylene glycol, which are likely to cause local irritation and toxicity, and are unreliable in safety.

[0006] At present, the preparation of florfenicol superfine powder has become the development trend of the industry, but florfenicol products are easy to crystallize, and it is very difficult to obtain superfine powder products

The ultrafine pulverization equipment common in the industry is not only inefficient, but also the particle size of the obtained micropowder is generally larger than 20 microns