Model for predicting prognosis of lung squamous cell carcinoma with seven genes as biomarkers, and establishing method thereof

A lung squamous cell carcinoma and prognosis technology, applied in the fields of genetic technology and biomedicine, can solve the problems of insensitive and accurate prognosis of lung squamous cell carcinoma, low overall survival rate, and no reference standard for prognosis judgment.
CN109859801APending Publication Date: 2019-06-07辽宁省肿瘤医院

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
辽宁省肿瘤医院
Publication Date
2019-06-07

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Abstract

The invention relates to a the field of biomedicine, and specifically relates to a model for predicting prognosis of lung squamous cell carcinoma with seven genes as biomarkers, and an establishing method thereof. The model for predicting prognosis of lung squamous cell carcinoma includes seven genes related to prognosis of lung squamous cell carcinoma: CSRNP1, CLEC18B, MIR27A, AC130456.4, DEFA6,ARL14EPL and ZFP42, wherein expressions of CSRNP1 and CLEC18B are positively correlated with a survival rate while expressions of MIR27A, AC130456.4, DEFA6, ARL14EPL and ZFP42 are negatively correlated with the survival rate. The model for predicting prognosis of lung squamous cell carcinoma provides a plurality of genes as biomarkers, and improves the prognosis sensitivity and accuracy for predicting lung squamous cell carcinoma, thereby reducing mortality and local recurrence rate in patients with lung squamous cell carcinoma, and improving the prognosis of patients through the risk prediction model.
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Description

technical field

[0001] The invention belongs to the field of gene technology and biomedicine, and specifically relates to a model containing seven genes as biomarkers to predict the prognosis of lung squamous cell carcinoma and a method for establishing it. Background technique

[0002] Squamous cell carcinoma of the lung, or squamous cell carcinoma of the lung, is one of the most important pathological types of lung cancer. It is derived from the malignant transformation of bronchial epithelial cells, and the number of cases accounts for about 30% of non-small cell lung cancer. Conventional treatment methods for lung squamous cell carcinoma mainly include surgical treatment, chemotherapy and molecular targeted therapy. The 5-year survival rate of patients is less than 15%, and more than 400,000 people die from it every year in the world. At present, there is no reference standard for the prognosis of patients with squamous cell carcinoma of the lung, and there is no specifi...

Claims

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