A kind of preparation method of gamma-carboxylated alkyl nitrile compound
A technology for carboxylated alkyl nitriles and compounds, which is applied in the field of preparation of γ-carboxylated alkyl nitrile compounds, can solve problems such as low efficiency and low efficiency, and achieve the effects of low price, easy source and high yield
Active Publication Date: 2021-09-17
NANCHANG HANGKONG UNIVERSITY
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However, there are fewer and inefficient methods for synthesizing such compounds in the prior art, requiring multi-step reactions and / or pre-designing and synthesizing reaction substrates with complex structures
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[0042] The present invention will be further described in detail below in conjunction with specific embodiments.
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The invention discloses a preparation method of gamma-carboxylated alkyl nitrile compounds. The method uses an olefin compound of formula II, a carboxylic acid compound of formula III, and an alkyl nitrile compound of formula IV in a nickel catalyst, silver A series of γ-carboxylated alkyl nitrile compounds with various structures were prepared by carrying out the difunctionalization reaction of olefins under the condition of oxidizing agent. The synthesis route of the gamma-carboxylated alkyl nitrile compound of the present invention has the advantages of easy source of raw materials, low price of the catalytic system, wide application range of reaction substrates and high yield of target products.
Description
technical field [0001] The application belongs to the technical field of organic synthesis, and in particular relates to a preparation method of gamma-carboxylated alkyl nitrile compounds. Background technique [0002] The rapid increase of molecular complexity from readily available chemicals (especially feedstocks derived from the petroleum industry, such as alkenes, alkanes, and aromatics) through mild, economical, and practical selective catalytic pathways is an important area of interest in academia and One of the main goals of the industry. In this field, the functionalization of molecules through the transformation of olefins and / or C–H bonds is an attractive and challenging goal, which has aroused great interest among researchers. Typical strategies include the two-carbon functionalization of alkenes, which extends the carbon chain by introducing two ortho-functional groups to give structurally complex compounds. However, most methods for the two-carbon functiona...
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IPC IPC(8): C07C253/30C07C255/38C07D307/68C07C319/20C07C321/28C07D333/24
Inventor 宋仁杰姜帅帅李金恒
Owner NANCHANG HANGKONG UNIVERSITY
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