Molecular classification and application of glioma based on cdc20 gene co-expression network

A CDC20-M, gene expression technology, applied in the biological field, can solve the problems of chromosomal instability, genome instability, etc.
CN109913549BActive Publication Date: 2021-02-05BEIJING NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING NORMAL UNIVERSITY
Publication Date
2021-02-05

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Abstract

The invention discloses glioma molecular typing based on CDC20 gene co-expression network and application and provides application of various gene expression matters in CDC20-M gene group and CREBRF-Mgene group for detecting glioma patients in the preparation of products for estimating prognosis risk of the glioma patients; the CDC20-M gene group is composed of 139 genes; the CREBRF-M gene groupis composed of 120 genes. It is verified herein that CDC20-M is a sensitive marker for poor prognosis for gliomas.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to a molecular classification and application of glioma based on CDC20 gene co-expression network. Background technique

[0002] Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system in adults, accounting for more than 50%. Although there have been many studies to explore the causes of glioblastoma and feasible treatment options, the survival period of patients with glioblastoma is still very short, with a median survival period of less than two years. Glioblastoma is in a continuous evolutionary process with complex cytological and genetic heterogeneity. The genome of glioblastoma contains many single nucleotide variations and is also characterized by chromosomal instability (CIN). Studies have found that glioblastoma cells have a high frequency of abnormal chromosome number events (non- euploid) and chromosomal structural variation events. Thes...

Claims

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