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Rhizoma belamcandae antiviral injection, preparation method thereof and intravenous administration antiviral injection

An injection and anti-virus technology, applied in anti-viral agents, drug delivery, pharmaceutical formulations, etc., can solve problems such as congestion, even muscle necrosis, inconvenient use, pain, etc., to extend the quality of life, avoid inconvenient use, Avoid the effect of degradation

Inactive Publication Date: 2019-07-02
李芳凯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Since the existing route of administration of Shegan Antiviral Injection is intramuscular injection, it is inconvenient to use clinically, the administration site of the patient is painful, and it is easy to cause adverse reactions such as congestion and even muscle necrosis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 500g of Shegan, 400g of Honeysuckle, 300g of Peilan, 200g of Capillary, 150g of Bupleurum, 250g of Dandelion, 400g of Radix Isatidis, and 300g of Folium Folium, add purified water 3 times the weight of the medicinal material, and use steam distillation to collect the distillate as 1% of the medicinal material. / 5, the distilled liquid is redistilled, and the refined liquid is about 1 / 8 of the weight of the medicinal material, and it is used for later use; the distilled medicinal residue is added to purified water 5 times the weight of the medicinal material, and boiled and decocted twice, each time for 1 hour, Filter through filter paper, combine the two filtrates, concentrate the filtrate, add 0.06% of the weight of the concentrated solution to the clarifier B, heat to 70-90°C, let stand for 2 hours, then add 0.03% of the weight of the concentrated solution to clarify Agent A, after standing still for 4 hours, centrifuge, pour out the supernatant, and concentrate t...

Embodiment 2

[0041] Take 50g of Shegan, 900g of honeysuckle, 100g of Peilan, 300g of capillary, 150g of Bupleurum, 250g of dandelion, 100g of Radix Isatidis, and 200g of Folium Folium. / 6, the distilled liquid is redistilled, and the refined liquid is about 1 / 7 of the weight of the medicinal material, and it is used for later use; the distilled medicinal residue is added to purified water 6 times the weight of the medicinal material, and boiled and decocted twice, each time for 1 hour, Filter through filter paper, combine the two filtrates, concentrate the filtrate, add 0.04% of the weight of the concentrated solution to the clarifier B, heat to 70-90°C, let stand for 2 hours, then add 0.02% of the weight of the concentrated solution to clarify Agent A, after standing for 4 hours, centrifuge, pour out the supernatant, and concentrate to 3g of crude drug per ml; add ethanol under slow stirring, add ethanol to make the alcohol content 75%, refrigerate at 4-8°C For 48 hours, filter through fi...

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PUM

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Abstract

The present invention relates to a rhizoma belamcandae antiviral injection, a preparation method thereof and an intravenous administration route of the rhizoma belamcandae antiviral injection, and belongs to the field of traditional Chinese medicine preparations. The rhizoma belamcandae antiviral injection comprises the following raw material medicines of rhizoma belamcandae, honeysuckle, herba eupatorii, herba artemisiae scopariae, radix bupleuri, dandelion, radix isatidis and folium isatidis. The raw material medicines are 1-1,000 parts by weight of rhizoma belamcandae, 1-1,000 parts by weight of honeysuckle, 1-1,000 parts by weight of herba eupatorii, 1-1,000 parts by weight of herba artemisiae scopariae, 1-1,000 parts by weight of radix bupleuri, 1-1,000 parts by weight of dandelion, 1-1,000 parts by weight of radix isatidis and 1-1,000 parts by weight of folium isatidis. Original medicinal materials in a prescription are subjected to water steam distilling, water boiling, clarifying agent adding, alcohol precipitating, water precipitating and other technical means to obtain effective active ingredients of each component of the rhizoma belamcandae antiviral injection, and sub-packaging and sterilizing are conducted to obtain the finished product preparation. The rhizoma belamcandae antiviral injection is high in bioavailability, simple to use and less in adverse reactions,and avoids inconvenience in clinical use, pains in administration sites of patients, and easily caused adverse reactions of blood stasis, even muscle necrosis, etc.

Description

technical field [0001] The invention relates to a Shegan antiviral injection, its preparation method and intravenous administration of the Shegan antiviral injection, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Shegan, also known as black fan, black pu, ghost fan, wild day lily, flat bamboo, golden butterfly, etc., is the dried rhizome of the perennial herbaceous plant Shegan; bitter and cold in nature; the main ingredients are Sheganding, irisin, iris flavonoids , Iris flavonoid glycosides, Sheganol, etc. Shegan water decoction has the effect of resisting pathogenic microorganisms. [0003] Honeysuckle, alias honeysuckle flower, silver flower, egret flower, Su flower, golden flower, double flower, two flower, two treasure flower, is a perennial semi-perennial green winding woody plant Lonicera, red gland honeysuckle, mountain silver flower Or the dry flower buds of Lonicera trichomes or the flowers with early opening;...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/08A61P31/12
CPCA61K9/0019A61K9/08A61K36/195A61K36/233A61K36/28A61K36/282A61K36/288A61K36/315A61K36/355A61K36/704A61K36/855A61K36/88A61K2236/37A61K2300/00
Inventor 李芳凯
Owner 李芳凯
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