Magnetic guidance device to assemble cell microcarriers
A technology of cell microcarriers and magnetic guidance, which is applied in the fields of enzymology/microbiology devices, biochemical cleaning devices, methods of supporting/immobilizing microorganisms, etc., and can solve the problems of unfavorable popularization and application of artificial tissue scaffolds and low work efficiency. Achieve the effect of flexible construction and efficient construction
Active Publication Date: 2019-07-05
CHONGQING TECH & BUSINESS UNIV
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[0006] Aiming at the problems of low work efficiency and unfavorable popularization and application of artificial tissue scaffolds in the in vitro construction of artificial tissues by robotic technology, the purpose of the present invention is to provide a device for magnetically guiding and assembling cell microcarriers, which can improve The orderly arrangement efficiency of micro-robots, the coordinated assembly of cell micro-carriers through magnetic-guided micro-manipulation robots and magnetic-guided devices, so that artificial tissue scaffolds can be constructed in a liquid environment in an orderly manner, providing a new method for the repair or replacement of damaged tissues and organs in the human body with means
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[0027] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.
[0028] see figure 1 As can be seen from the figure, the device for magnetically guiding and assembling cell microcarriers of the present invention includes a magnetically guiding micro-manipulation robot 1 and a magnetic guiding device 2; Composed of 12 magnets, the body of the micro-manipulation robot has three degrees of freedom and nano-level motion accuracy in translation in the three directions of X, Y, and Z. The body of the micro-manipulation robot that realizes this function is directly available in existing products. What the invention actually adopts is the micro-manipulation robot body produced by Newport Company of the United States, the model is 9062-XYZ-PPP-M. One end of the mechanical arm is connected to the body of the micro-manipulation robot, and the miniature permanent magnet 12 is installed on the other end of the mechani...
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Abstract
The invention discloses a magnetic guidance device to assemble cell microcarriers, comprising a magnetic guidance microoperation robot and a magnetic guidance device. The magnetic guidance microoperation robot comprises a microoperation robot body, a mechanical arm and a miniature permanent magnet and has three degrees of freedom of translation in X, Y and Z directions and nano-level motion precision; the microoperation robot body is connected with one end of the mechanical arm, and the other end of the mechanical arm is provided with the miniature permanent magnet; a cell microcarrier can beoperated in noncontact manner through magnetic force; the magnetic guidance device comprises a permanent magnet, a culture dish and a soft magnetic wire array; magnetic induction intensity of formed dot matrix allows cell microcarriers to be arranged orderly. The magnetic guidance device to assemble cell microcarriers has the advantages that ordered arrangement efficiency can be improved for a miniature robot, the cell microcarriers are assembled through cooperation of the magnetic guidance microoperation robot and the magnetic guidance device, an artificial tissue scaffold can be constructedorderly in a liquid environment, and a novel method and means are provided for restoring or replacing affected tissue or organs of human bodies.
Description
technical field [0001] The invention relates to the technology of using cell microcarriers to construct artificial tissue scaffolds, in particular to a device for magnetically guiding and assembling cell microcarriers, which belongs to the technical field of cell three-dimensional assembly in tissue engineering. Background technique [0002] Human daily life is full of unpredictable natural disasters and behavioral accidents, which can easily cause tissue damage and organ loss, and the aging and degeneration of tissues and organs also threaten human health. In order to solve the problems of shortage of donors, difficulty in matching and immune rejection, tissue engineering develops artificial tissues that can replace human organ functions through three-dimensional assembly of cell microcarriers, which is conducive to non-invasive repair of trauma and functional reconstruction of autogenous tissues. The combination of robotics and biomedicine provides new methods for organ re...
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IPC IPC(8): C12M1/00C12M1/42B25J7/00
CPCC12M25/14C12M35/06B25J7/00
Inventor 李兴富
Owner CHONGQING TECH & BUSINESS UNIV