Use of glaucocalyxin A in preparation of medicament for treating liver cancer

A technology of Wangzaozi B and treatment of liver cancer, applied in the fields of biochemistry and molecular biology, can solve the problems of large side effects and damage to the human body's own immunity

Inactive Publication Date: 2019-08-02
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since not all patients with liver cancer are suitable for surgical treatment, even after surgical treatment, it may not be able to improve the quality of life of the patients; the anti-tumor chemotherapy drugs commonly used in clinical practice have relatively large side effects on the human body, and the treatment process will damage the human body. Adverse factors such as autoimmunity

Method used

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  • Use of glaucocalyxin A in preparation of medicament for treating liver cancer
  • Use of glaucocalyxin A in preparation of medicament for treating liver cancer
  • Use of glaucocalyxin A in preparation of medicament for treating liver cancer

Examples

Experimental program
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Embodiment

[0025] Example: Extraction and Verification of Wangzaozi B

[0026] Refer to CN105585471A to extract and verify Wangzaozi B. Briefly, the extraction steps are as follows: (1) The root of Wangzaozi is crushed with an ordinary pulverizer, and passed through a 40-mesh sieve to obtain the coarse powder of Wangzaozi root; (2) Accurately weigh the root of Wangzaozi Coarse powder 5.0kg, add 60gNaHCO 3 Mix the additives evenly, grind them in a super mill for 40 minutes, pass through a 300-mesh sieve, accurately weigh 2.0 kg and put them in a beaker, add 80% ethanol aqueous solution according to the ratio of material to liquid 1:24, and stir evenly; (3 ) was ultrasonically extracted at 45°C, frequency 43kHz, and power 250W for 50 minutes, and the extract was vacuum filtered to obtain a filtrate, which was concentrated under reduced pressure at 40°C and 60r / min to obtain a concentrate; (4) the concentrate was sequentially Through petroleum ether and chloroform extraction; (5) take the ...

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Abstract

The invention discloses use of glaucocalyxin A in the preparation of a medicament for treating liver cancer. Specifically, the invention discloses the action of the glaucocalyxin A on liver cancer cells, and by destroying the mitochondrial membrane potential, causing Cyto-C outflow, inhibiting anti-apoptotic protein Bcl-2, promoting the expression of pro-apoptotic protein Bax, and triggering caspase cascade reaction to induce apoptosis, a new therapeutic medicament for the treatment of liver cancer is provided.

Description

technical field [0001] The invention belongs to the technical field of biochemistry and molecular biology, and specifically relates to the use of wangzaozi B in the preparation of medicines for treating liver cancer. Background technique [0002] Primary liver cancer (PLC) is one of the most common malignant tumors in China, with high morbidity and high mortality. Because the cause of PLC is relatively hidden and the early symptoms are not obvious, when many patients are diagnosed, most of them are already in the middle and late stage, which seriously threatens human life and health. [0003] PLC includes hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Among them, hepatocellular carcinoma is the most common and aggressive, and its incidence is increasing year by year. The etiology of HCC is diverse, mainly including chronic hepatitis, alcoholism, and obesity. Intrahepatic cholangiocarcinoma is the second most common primary liver cancer and can be divided in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P35/00
CPCA61K31/122A61P35/00
Inventor 薛宏宇苗诗雨牛蕾连显会王宁周玉荣刘勇姜丽丽刘亚军
Owner DALIAN UNIV OF TECH
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