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Biological polysaccharide with hair growth and hair loss prevention and its application

A kind of use, glucan technology, applied in the field of biotechnology and pharmaceutical preparations, can solve problems such as lack of hair growth drugs

Active Publication Date: 2022-06-28
ZHEJIANG GLLION BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of society, people pay more and more attention to the hair that has both protective and aesthetic effects, but there is still a lack of clinically effective hair growth-stimulating drugs

Method used

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  • Biological polysaccharide with hair growth and hair loss prevention and its application
  • Biological polysaccharide with hair growth and hair loss prevention and its application
  • Biological polysaccharide with hair growth and hair loss prevention and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0224] Example 1, acquisition and determination of β-glucan

[0225] This embodiment only takes the β-glucan obtained by fermentation of Schizophyllum as an example, but is not limited thereto.

[0226] 1. Obtaining the fermentation broth of Schizophyllum bacteria

[0227] The fermentation broth in the following examples was prepared by fermenting Schizophyllum species (Schizophyllum communeFr-1003, product catalogue: 38548 TM , purchased from the American Type Culture Collection Center [ATCC]), as follows:

[0228] 1. Activation of Schizophyllum strains: 200g / L of potato, 30g / L of glucose, 10g / L of sodium chloride and 20g / L of agar are made into a plate medium, and the strain of Schizophyllum is inoculated on the plate medium , cultured in a constant temperature incubator at 25°C for 7 days to obtain flat mycelium;

[0229] 2. Seed activation: put the liquid medium made of potato starch 100g / L, glucose 40g / L, yeast extract 2g / L, yeast extract powder 2g / L, and water into ...

Embodiment 2

[0281] Example 2 β-glucan promotes hair growth experiment (rat)

[0282] 1. Experimental method

[0283] 1. Take 8 Wistar rats as spares;

[0284] 2. Take 100g of rosin and paraffin in a small beaker, heat, melt and mix in a boiling water bath, and keep at 70°C to prevent solidification for later use;

[0285] 3. Weigh the body weight of each rat, and perform intraperitoneal injection anesthesia with trichloroacetaldehyde according to the dosage of 0.3% of the body weight;

[0286] 4. Select an area on the left and right sides of the back of the anesthetized rat, apply an appropriate amount of the rosin-paraffin wax mixture evenly, and after cooling and solidify for a while, peel it off against the direction of hair growth to expose the hairless rat back skin;

[0287] 5. The rats were divided into two groups after hair removal, and 1 mg / mL glycerol and 1 mg / mL Schizophyllum β-glucan (prepared according to the method of Example 1) were smeared on both sides of the back of ea...

Embodiment 3

[0291] Example 3 Beta-glucan optimizes the basic properties of AES

[0292] 1. Experimental method

[0293] 1. Take two tubes of 25 mL 10% AES aqueous solution, add 1 mg / mL Schizophyllum β-glucan (prepared according to the method in Example 1) in the experimental group, and add 1 mg / mL deionized water in the control group. The two tubes were mixed and shaken vigorously for 30 s, and the amount of foam produced was immediately observed.

[0294] 2. Take two tubes of 25 mL 10% AES aqueous solution, add 1 mg / mL Schizophyllum β-glucan (prepared according to the method in Example 1) in the experimental group, and add 1 mg / mL deionized water in the control group. The two tubes were mixed and shaken vigorously for 30 s, and the defoaming speed was observed immediately.

[0295] 3. Take two tubes of 25 mL 10% AES aqueous solution, add 1 mg / mL Schizophyllum β-glucan (prepared according to the method in Example 1) in the experimental group, and add 1 mg / mL deionized water in the contr...

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Abstract

The invention relates to a biological polysaccharide with the functions of hair growth, hair fixation and hair loss prevention and its application. Specifically, the β-glucan in the present invention, especially the β-glucan with natural solubility, high molecular weight and high viscosity (such as Schizophyllum β-glucan), can very effectively promote hair growth and / or to prevent hair loss. Experiments have shown that β-glucan can significantly promote the telogen hair follicles to enter the growth phase, make them stay in the growth phase for a long time, promote hair regeneration and hair growth, prevent hair loss, strengthen hair roots, and have the ability to remove and prevent dandruff, and Antipruritic effect.

Description

technical field [0001] The present invention relates to the field of biotechnology and pharmaceutical preparations, in particular to a biological polysaccharide with the effect of hair growth and hair loss prevention and its application. Background technique [0002] Hair growth is a cyclic and periodic process, which mainly goes through three processes: anagen stage, catagen stage, and telogen stage. Hair growth is not only affected by age, gender, and location, but also by hormone levels, diseases, and external factors. [0003] Hair has the function of defense, protection and increased communication and aesthetics. Hair is produced from hair follicles, which are complex appendages of the skin that go through a cycle of growth, catagen, and telogen growth. Once the hair follicle cycle is disordered, it will affect the normal growth of hair follicles and lead to the occurrence of hair loss diseases. With the development of society, people pay more and more attention to h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/73A61K31/716A61K45/06A61P17/14A61P17/00A61Q7/00
CPCA61K8/73A61K31/716A61K45/06A61P17/14A61P17/00A61Q7/00A61K2300/00
Inventor 郭宏亮叶榛吴佳迪庄秀园林檬王轩朱勤健
Owner ZHEJIANG GLLION BIOTECH CO LTD
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