Tea tree essential oil enteric coating pellet as well as preparation method and application thereof

A technology of tea tree essential oil and enteric coating, which is applied in the directions of application, extrusion and granulation of raw materials, and additional food elements, etc., can solve problems such as instability of tea tree essential oil, achieve good feeding effect, high safety, and prevent animal diseases. Effect

Active Publication Date: 2019-08-16
天津中澳嘉喜诺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to provide a tea tree essential oil enteric-coated pellet and its preparation method and application. The tea tree essential oil enteric-coated pellet provided by the invention can effectively solve the problem of tea tree essential oil being unstable, vol

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  • Tea tree essential oil enteric coating pellet as well as preparation method and application thereof
  • Tea tree essential oil enteric coating pellet as well as preparation method and application thereof
  • Tea tree essential oil enteric coating pellet as well as preparation method and application thereof

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preparation example Construction

[0044] The raw materials for preparing the pellet core include cellulose, excipients and water;

[0045] The preparation raw materials of the coating liquid include: methacrylic acid-ethyl acrylate copolymer, inorganic filler, anti-photolysis material, coating material, plasticizer and water.

[0046] In the present invention, unless otherwise specified, all raw material components are commercially available products well known to those skilled in the art.

[0047] In the present invention, the raw materials for preparing the tea tree essential oil enteric coated pellets in parts by weight include 40-50 parts of the pellet core, preferably 41-48 parts, more preferably 41-45 parts, and most preferably 41 parts. ~43 copies. In the present invention, the diameter of the core pellets is preferably 0.8 to 1.0 mm, more preferably 0.8 mm. In the present invention, the raw materials for preparing the pellet core include cellulose, excipients and water. In the present invention, the cellul...

Embodiment 1

[0066] Mix 5.6 kg of microcrystalline cellulose, 1.9 kg of pregelatinized starch and 4.5 kg of pure water, and extrude the obtained soft material with an extruder to obtain a strip with a length of 10 cm and a diameter of 0.8 mm, and then add the obtained strip Go to the spheronizer to make a pellet core with a diameter of 0.8mm;

[0067] Heat 5.7 kg of polyethylene glycol 12000 to a molten state, add 2.0 kg of tea tree essential oil and stir and mix to obtain a tea tree essential oil-polyethylene glycol mixture;

[0068] Stir and condense the pellet core and the tea tree essential oil-polyethylene glycol mixture, so that the tea tree essential oil-polyethylene glycol mixture is evenly wrapped on the pellet core, and the fine powder is removed through a 50-mesh sieve to obtain a drug-loaded pellet core;

[0069] Combine 35g sodium carboxymethyl cellulose, 80g polyethylene glycol 6000, 50g triethyl citrate, 830g talc, 500g titanium dioxide, 1.67kg methacrylic acid-ethyl acrylate copol...

Embodiment 2

[0072] Mix 3.8 kg of microcrystalline cellulose, 0.13 kg of pregelatinized starch and 3 kg of pure water, and extrude the obtained soft material with an extruder to obtain a strip with a length of 10 cm and a diameter of 0.8 mm, and then add the obtained strip to Pellets with a diameter of 0.8mm are made in the rounding machine;

[0073] Heat 3.8 kg of polyethylene glycol 12000 to a molten state, add 1.8 kg of tea tree essential oil and stir and mix to obtain a tea tree essential oil-polyethylene glycol mixture;

[0074] Stir and condense the pellet core and the tea tree essential oil-polyethylene glycol mixture, so that the tea tree essential oil-polyethylene glycol mixture is evenly wrapped on the pellet core, and the fine powder is removed through a 50-mesh sieve to obtain a drug-loaded pellet core;

[0075] Combine 25g sodium carboxymethyl cellulose, 55g polyethylene glycol 6000, 35g triethyl citrate, 600g talc, 350g titanium dioxide, 1.15kg methacrylic acid-ethyl acrylate copoly...

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Abstract

The invention provides a tea tree essential oil enteric coating pellet as well as a preparation method and application thereof, and belongs to the technical field of animal husbandry feeds. The tea tree essential oil enteric coating pellet is prepared from the following components in parts by weight: 40-50 parts of a pellet core, 25-35 parts of a tea tree essential oil-auxiliary material mixture and 25-35 parts of a coating solution. Raw materials for preparing the pill core comprise cellulose, an excipient and water. The coating liquid is prepared from the following raw materials: a methacrylic acid-ethyl acrylate copolymer, inorganic filler, a photolysis resistant material, a coating material, a plasticizer and water. The product can effectively solve the problem that tea tree essentialoil volatilizes easily and special essential oil smell affects animal food intake, effectively reduce the incidence rate of diarrhea and other diseases, remarkably increase the animal food intake, improve the feed conversion efficiency, and is high in safety and free of drug resistance. The product can be added into feed to replace the use of growth-promoting antibiotics in feed additives.

Description

Technical field [0001] The invention relates to the technical field of animal husbandry feed, in particular to a tea tree essential oil enteric coated pellets and a preparation method and application thereof. Background technique [0002] In recent years, the problem of bacterial drug resistance has attracted widespread attention from all over the world. The unreasonable application and even abuse of antibiotics is one of the important factors that cause bacterial resistance. Among them, the problem of antibiotic abuse in animal husbandry is particularly serious. Threatening human health. [0003] Plant essential oils are secondary metabolites in plants. Among them, the antibacterial activity of Australian tea tree essential oil has been widely recognized by the medical field, production practice and researchers. It has antibacterial, anti-inflammatory, antioxidant and other biological activities, which can promote animal growth and To prevent animal diseases, its good antibacteri...

Claims

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Application Information

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IPC IPC(8): B01J2/02B01J2/20A23K20/10A23K20/105A23K20/158A23K20/20A23K40/30
CPCA23K20/10A23K20/105A23K20/158A23K20/20A23K40/30B01J2/02B01J2/20
Inventor 孟杰民胡少青范惠章马吉飞王子波
Owner 天津中澳嘉喜诺生物科技有限公司
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