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Application of chitosan-based nanofibrous membrane for medical wound dressing

A nanofiber membrane and wound dressing technology, which is applied in the field of preparation of chitosan-based nanofiber membranes, can solve the problems of poor drug release sustainability and low drug release rate, and achieve sustained release, high drug release rate, and bacteriostasis. active effect

Active Publication Date: 2021-12-07
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention solves the problems of poor drug release persistence and low drug release rate of existing medical wound dressings, and provides a preparation method of chitosan-based drug-loaded nanofiber membranes that can be applied to medical wound dressings

Method used

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  • Application of chitosan-based nanofibrous membrane for medical wound dressing
  • Application of chitosan-based nanofibrous membrane for medical wound dressing
  • Application of chitosan-based nanofibrous membrane for medical wound dressing

Examples

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specific Embodiment approach 1

[0029] Specific embodiment one: present embodiment a kind of preparation method that can be applied to the chitosan-based drug-loaded nanofiber film of medical wound dressing, it is carried out according to the following steps:

[0030] 1. Preparation of spinning precursor solution:

[0031] ①. Add chitosan to distilled water, then add glacial acetic acid, stir evenly to obtain chitosan solution;

[0032] The mass percent of chitosan in the described chitosan solution is 2%~5%; The mass ratio of the volume of described glacial acetic acid and chitosan is (0.5~1)mL:1g;

[0033]②. Add polyvinyl alcohol to distilled water, soak for 4h-8h, then place it in a water bath, and stir at a constant temperature at a temperature of 70°C-90°C until the polyvinyl alcohol is completely dissolved, then let it stand and cool to obtain polyvinyl alcohol. Vinyl alcohol solution;

[0034] The mass percent of polyvinyl alcohol in the polyvinyl alcohol solution is 5% to 10%;

[0035] ③. Add dry ...

specific Embodiment approach 2

[0044] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the degree of deacetylation of the chitosan described in step ① is 90% to 91%. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0045] Specific embodiment 3: The difference between this embodiment and specific embodiment 1 or 2 is that the drug described in step 1 ④ is ciprofloxacin or ciprofloxacin hydrochloride. Others are the same as in the first or second embodiment.

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Abstract

The invention relates to an application of a chitosan-based nanofiber membrane of a medical wound dressing, and relates to a preparation method of a chitosan-based nanofiber membrane. The invention solves the problems of poor drug release continuity and low drug release rate of the existing medical wound dressings. The preparation method comprises the following steps: 1. preparing spinning precursor; 2. preparing a drug-loaded nanofiber film to obtain a chitosan-based drug-loaded nanofiber film that can be applied to medical wound dressings. The invention relates to the preparation of the chitosan-based drug-loaded nanofiber film used for medical wound dressing.

Description

technical field [0001] The invention relates to a preparation method of a chitosan-based nanofiber membrane. Background technique [0002] Electrospinning technology is a commonly used method to prepare nanoscale fibers through the electric field force between the spinning solution and the collecting plate. Its main advantages are simple operation process, low cost and wide application fields of finished fibers. Nanofibers prepared by electrospinning technology have extremely high specific surface area and porosity, and have broad application prospects and application value. The characteristics of this high specific surface area and high porosity are exactly what wound dressings need, satisfying its breathable and drug-carrying structure. Chitosan, obtained by partial deacetylation of chitin, has special physical and chemical properties and excellent biological properties, such as biocompatibility, biodegradability, non-toxicity and antibacterial activity. Chitosan has pot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/18A61L15/42A61L15/44A61L15/46D01F8/18D01F8/10D01F1/10D04H3/005D01D1/02D01D5/00
CPCA61L15/18A61L15/24A61L15/28A61L15/42A61L15/44A61L15/46A61L2300/406A61L2300/412A61L2300/602A61L2400/12D01D1/02D01D5/003D01D5/0069D01D5/0092D01F1/10D01F1/103D01F8/10D01F8/18D04H3/005C08L5/08C08L29/04
Inventor 张大伟杨帅刘永旭陈思佳
Owner NORTHEAST FORESTRY UNIVERSITY