Preparation and application of medicine for inhibiting hepatic stellate cell activation

A technology of hepatic stellate cells and traditional Chinese medicine, applied in drug combination, digestive system, pharmaceutical formulations, etc., can solve problems such as poor treatment effect of liver fibrosis, and achieve inhibition of hepatic stellate cell activation and proliferation, promotion of apoptosis, and reduction of collagen. effect of deposition

Inactive Publication Date: 2019-08-30
GUANGXI MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a new traditional Chinese medicine monomer that effectively inhibits the activation of hepatic stellate cells, so as to alleviate the problem of poor therapeutic effect on liver fibrosis

Method used

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  • Preparation and application of medicine for inhibiting hepatic stellate cell activation
  • Preparation and application of medicine for inhibiting hepatic stellate cell activation
  • Preparation and application of medicine for inhibiting hepatic stellate cell activation

Examples

Experimental program
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Embodiment Construction

[0011] One, the preparation of anthorolactone

[0012] Extraction and separation method: take 5kg of dried whole grass of Goose Bubivora, crush it, heat and reflux extraction with 95% ethanol for 3 times, each time for 2 hours, combine the ethanol extracts for 3 times, remove ethanol under reduced pressure, and obtain 880g of Goose Bubivory ethanol extract . Take the ethanol extract and add appropriate amount of distilled water to resuspend, filter with a 0.45um filter head, and extract with petroleum ether, ethyl acetate and n-butanol in sequence to obtain 126.8g of ethyl acetate extract. Separation with silica gel (1.5kg, 200-300 mesh) column chromatography, PE: EtOAc (7:1,4:1,3:1,2:1,1:1,1:2), EtOAc, EtOAc (5 %MeOH), EtOAc (10% MeOH), EtOAc (20% MeOH) gradient elution, thin-layer chromatography collects the same fraction, wherein, the eighth fraction is passed through a silica gel column (chloroform:methanol, 90:10) and Sephadex LH- 20 column (methanol: water, 1:1) for fu...

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Abstract

The invention discloses preparation and application of traditional Chinese medicine herba centipedae active monomer component helenalin. A monomeric compound helenal is separated from the traditionalChinese medicine herba centipedae; experiments prove that the helenal can effectively inhibit herba centipedae activation and proliferation, reduce collagen deposition and reduce synthesis of inflammation-related protein, and the mechanism may be related to inhibition of PI3K/Akt channel signal conduction. A new traditional Chinese medicine monomer for effectively inhibiting hepatic stellate cellactivation is provided for treating hepatic fibrosis.

Description

technical field [0001] The invention relates to a preparation method and application of a medicine, in particular to a method for extracting and isolating the active monomer component of the traditional Chinese medicine geese not herbivorous, antalolide; and the inhibitory effect of the antalolide on the activation of hepatic stellate cells. Background technique [0002] Liver fibrosis is a repair response of the liver to acute and chronic liver damage caused by inflammation, viruses and other factors, which can further develop into cirrhosis or liver cancer, which seriously threatens the lives and health of the people. The activation and proliferation of hepatic stellate cells is considered to be the central link in the occurrence and development of liver fibrosis. The core strategy for the treatment of liver fibrosis is to inhibit the activation and proliferation of hepatic stellate cells. On the basis of traditional Chinese medicine theory and long-term clinical practice...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K36/28A61P1/16
CPCA61K31/365A61K36/28A61P1/16
Inventor 林兴黄权芳白法承韦锦斌黄仁彬温淑娟韦园园张晓琳
Owner GUANGXI MEDICAL UNIVERSITY
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