Preparation and application of medicine for inhibiting hepatic stellate cell activation
A technology of hepatic stellate cells and traditional Chinese medicine, applied in drug combination, digestive system, pharmaceutical formulations, etc., can solve problems such as poor treatment effect of liver fibrosis, and achieve inhibition of hepatic stellate cell activation and proliferation, promotion of apoptosis, and reduction of collagen. effect of deposition
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[0011] One, the preparation of anthorolactone
[0012] Extraction and separation method: take 5kg of dried whole grass of Goose Bubivora, crush it, heat and reflux extraction with 95% ethanol for 3 times, each time for 2 hours, combine the ethanol extracts for 3 times, remove ethanol under reduced pressure, and obtain 880g of Goose Bubivory ethanol extract . Take the ethanol extract and add appropriate amount of distilled water to resuspend, filter with a 0.45um filter head, and extract with petroleum ether, ethyl acetate and n-butanol in sequence to obtain 126.8g of ethyl acetate extract. Separation with silica gel (1.5kg, 200-300 mesh) column chromatography, PE: EtOAc (7:1,4:1,3:1,2:1,1:1,1:2), EtOAc, EtOAc (5 %MeOH), EtOAc (10% MeOH), EtOAc (20% MeOH) gradient elution, thin-layer chromatography collects the same fraction, wherein, the eighth fraction is passed through a silica gel column (chloroform:methanol, 90:10) and Sephadex LH- 20 column (methanol: water, 1:1) for fu...
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