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A device for capturing, processing and reinfusing circulating tumor cells to stimulate immunity and its application

A technology of tumor cells and processing units, which is applied in the direction of blood circulation processing, drug devices, and other medical devices, which can solve the problems of high recurrence rate, small scope of application, and high technical cost, and achieve stable curative effect, wide applicability, and convenience. The effect of wearing

Active Publication Date: 2021-09-28
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such immunotherapy technology is costly, has a high recurrence rate, and has a small scope of application, and has not fundamentally solved the problem of tumor cell immune escape.

Method used

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  • A device for capturing, processing and reinfusing circulating tumor cells to stimulate immunity and its application
  • A device for capturing, processing and reinfusing circulating tumor cells to stimulate immunity and its application
  • A device for capturing, processing and reinfusing circulating tumor cells to stimulate immunity and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Combined with the manual Figure 1-2As shown, a device for capturing, processing, and reinfusing circulating tumor cells to stimulate immunity includes a housing 31, a blood transfusion unit, a CTCs capture and processing unit 5, and an energy supply unit 10. The blood transfusion unit includes two airtight indwelling The needles 9 are respectively located at the blood extraction place and the blood reinfusion place; each of the two indwelling needles 9 is attached with a strap 8, and the strap 8 is made of cotton and linen; the rear part of the indwelling needle 9 is connected with a A blood transfusion vessel 30, the blood transfusion vessel 30 is connected in series with an indwelling needle 9, an air bubble detector 6, a blood pump 3 and a heparin pump 1, and the hemostatic clip 7 is arranged between the indwelling needle 9 and the air bubble detector 6, and is fixed on the infusion vessel On the blood vessel 30, the heparin pump 1 is provided with a heparin pool, t...

Embodiment 2

[0041] Combined with the manual Figure 1-3 Shown, on the basis of embodiment 1 device, this device is further improved.

[0042] The monitoring module includes a temperature sensing element placed on the inner wall of the operation pool 11, a blood sensor 2 placed on the inner wall of the blood transfusion vessel 30, an external interaction system 24, a buzzer element 25 and a data analysis system 26. The external interaction system 24 communicates with the data The analysis system 26 is connected in parallel inside the monitoring unit; the buzzer element 25 is located above the outer surface of the monitoring unit 4, and is connected to the external interactive system 24 with wires, and the temperature sensing element is connected to the monitoring unit 4 with a data line 27; The external interaction system 24 and the data analysis system 26 are connected to other units through data lines; the blood sensor 2 can analyze, compare and transmit the collected data inside the bod...

Embodiment 3

[0045] Combined with the manual Figure 1-2 Shown, on the basis of embodiment 2 device, this device is done practical design.

[0046] have the device integrated in a portable container, as described in the attached Figure 4 As shown, the housing 31 is a backpack type container, and each unit of the device is fixedly arranged in the inner space of the housing 31 . The surface of the housing 31 adopts a water-repellent coating to prevent rainwater from affecting the devices in the housing. The side of the housing 31 is provided with a hole for the blood transfusion vessel 30 to penetrate and pass through. The front end of the blood transfusion vessel 30 is connected with an indwelling needle 9, and the indwelling needle 9 is adhered to an adjustable elastic wide waterproof On the strap 8, the strap 8 is convenient for the user to fix the needle and avoid infection, and the material of the strap 8 is a mixed textile material.

[0047] The use of this portable design will max...

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Abstract

A device for capturing, processing and reinfusing circulating tumor cell CTCs to stimulate immunity and its application, the device includes a blood transfusion unit, a CTCs capture and processing unit, a monitoring unit and an energy supply unit; the blood transfusion unit injects the user's blood In the device, the treated blood is returned to form a blood circuit; the blood circuit is connected with a CTCs capture and processing unit and a monitoring unit; the energy supply unit is connected with other units by wires. The device captures and processes CTCs and infuses the processed CTCs back into the human body to stimulate an immune response, achieve the effect of adjuvant treatment of tumors, and also prevent tumors from spreading through peripheral blood to a certain extent, thereby reducing the risk of cancer cell metastasis. The versatility and reusability of the device of the present invention also greatly reduces the cost compared with existing immunotherapy.

Description

technical field [0001] The invention belongs to the field of tumor immunotherapy, and specifically relates to a device for capturing, processing and transfusing circulating tumor cell CTCs to stimulate immunity and its application. Background technique [0002] Every year, more than 14 million people worldwide are diagnosed with cancer, and about 8.2 million of them will eventually die of cancer, and the death toll is expected to double by 2030. It can be seen that cancer has become one of the main killers of modern humans. This long-standing difficulty in the medical field has gradually developed into the sword of Damocles hanging over people's heads, threatening everyone's life safety at all times. [0003] At present, the main treatment methods for cancer are surgery, radiotherapy and chemotherapy. As a mechanical method, surgery is a thorough local treatment, but since cancer cells will proliferate or metastasize to the surrounding and distant places, the recurrence or...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/36
CPCA61M1/3626A61M1/369A61M2202/0413A61M1/3618A61M2202/0021
Inventor 夏侯博严东楠沈靖菲查可扬魏新若周若晨
Owner SOUTHEAST UNIV
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