Application of L-serine to prevention or treatment of high-altitude craniocerebral injury

A craniocerebral injury and serine technology is applied in the application field of L-serine in the prevention or treatment of high altitude craniocerebral injury, which can solve the problem of lack of clinical neuroprotective agents, and achieves promotion of repair, increase in quantity, and inhibition of the expression of inflammatory factors. Effect

Inactive Publication Date: 2019-09-27
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, more and more evidence now shows that white matter damage plays an important role in brain injury, but there is still a lack of effective clinical neuroprotective agents, so the need for treatment of white matter damage at high altitudes is becoming more and more urgent and other technical issues

Method used

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  • Application of L-serine to prevention or treatment of high-altitude craniocerebral injury
  • Application of L-serine to prevention or treatment of high-altitude craniocerebral injury
  • Application of L-serine to prevention or treatment of high-altitude craniocerebral injury

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Effect test

Embodiment 1

[0039] The application of L-serine in the prevention or treatment of plateau craniocerebral injury, the steps are:

[0040] The first step is to establish a mouse plateau model: C57BL / 6 mice are placed in a hypobaric oxygen chamber to simulate an altitude of 4000m for simulated plateau culture, and the pressure in the hypobaric oxygen chamber is -39.7kPa;

[0041] The second step is to anesthetize the mice after cultured at high altitude: take the mice out of the hypobaric oxygen chamber after 3 days, anesthetize the mice with an intraperitoneal injection of anesthesia, and fix the anesthetized mice on the brain stereotaxic instrument, and the anesthesia adopts mass fraction 10% chloral hydrate, the anesthetic dose is 0.01mL / kg;

[0042]The third step is to establish the mouse model of plateau craniocerebral injury: sterilize and incise the mouse scalp to expose the bregma and determine the position of the bregma, 1.5 mm in front of the bregma and 1.5 mm to the right side of t...

Embodiment 2

[0048] The application of L-serine in the prevention or treatment of plateau craniocerebral injury, the steps are:

[0049] The first step is to establish a mouse plateau model: C57BL / 6 mice are placed in a hypobaric oxygen chamber to simulate an altitude of 4000m for simulated plateau culture, and the pressure in the hypobaric oxygen chamber is -39.7kPa;

[0050] The second step is to anesthetize the mice after cultured at high altitude: take the mice out of the hypobaric oxygen chamber after 3 days, anesthetize the mice with an intraperitoneal injection of anesthesia, and fix the anesthetized mice on the brain stereotaxic instrument, and the anesthesia adopts mass fraction 10% chloral hydrate, the anesthetic dose is 0.01mL / kg;

[0051] The third step is to establish the mouse model of plateau craniocerebral injury: sterilize and incise the mouse scalp to expose the bregma and determine the position of the bregma, 1.5 mm in front of the bregma and 1.5 mm to the right side of ...

Embodiment 3

[0057] The application of L-serine in the prevention or treatment of plateau craniocerebral injury, the steps are:

[0058] The first step is to establish a mouse plateau model: C57BL / 6 mice are placed in a hypobaric oxygen chamber to simulate an altitude of 4000m for simulated plateau culture, and the pressure in the hypobaric oxygen chamber is -39.7kPa;

[0059] The second step is to anesthetize the mice after cultured at high altitude: take the mice out of the hypobaric oxygen chamber after 3 days, anesthetize the mice with an intraperitoneal injection of anesthesia, and fix the anesthetized mice on the brain stereotaxic instrument, and the anesthesia adopts mass fraction 10% chloral hydrate, the anesthetic dose is 0.01mL / kg;

[0060] The third step is to establish the mouse model of plateau craniocerebral injury: sterilize and incise the mouse scalp to expose the bregma and determine the position of the bregma, 1.5 mm in front of the bregma and 1.5 mm to the right side of ...

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Abstract

The invention discloses application of L-serine to prevention or treatment of high-altitude craniocerebral injury. A used model is a high-altitude brain injury mouse model, and by putting a C57BL / 6 mouse into a hypobaric oxygen chamber and simulating the altitude of 4000m, CCI cortical impact is performed after 3 days to cause high-altitude traumatic brain injury and then L-serine treatment is performed; results of behavioral experiments Rotarod test, Beam walking test and Corner show that after L-serine treatment, the sensorimotor function of the mouse after the high-altitude brain injury is restored somewhat; in addition, Nissl staining and fast blue staining find that after the L-serine treatment, the number of neurons in the hippocampal CA3 area can be significantly increased, so that a certain role in repairing the damage of cerebral white matter in a high-altitude environment is also played and repair of the sensorimotor function of a patient suffering from the high-altitude craniocerebral injury is promoted.

Description

technical field [0001] The invention relates to the application technical field of L-serine, in particular to the application of L-serine in preventing or treating plateau craniocerebral injury. Background technique [0002] The human brain is mainly composed of white matter and gray matter, and the gray matter of the brain is also called the cerebral cortex. Gray matter is mainly composed of neuron cell bodies and unmyelinated axons. It is the central processing unit of the central nervous system and is responsible for many advanced functions of the brain; white matter is mainly composed of axons wrapped in myelin sheath and various glial cells. , including the corpus callosum, internal capsule, anterior commissure, and striatal fiber tracts. White matter has the function of responding to motor and sensory information from the cerebral cortex and responding to its signals to the cerebral cortex, and plays an important role in signal transduction and other aspects. [0003...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P25/00
CPCA61K31/198A61P25/00
Inventor 王国华孙叶超姜正林周佳敏徐丽华
Owner NANTONG UNIVERSITY
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