Application of L-serine to prevention or treatment of high-altitude craniocerebral injury
A craniocerebral injury and serine technology is applied in the application field of L-serine in the prevention or treatment of high altitude craniocerebral injury, which can solve the problem of lack of clinical neuroprotective agents, and achieves promotion of repair, increase in quantity, and inhibition of the expression of inflammatory factors. Effect
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Embodiment 1
[0039] The application of L-serine in the prevention or treatment of plateau craniocerebral injury, the steps are:
[0040] The first step is to establish a mouse plateau model: C57BL / 6 mice are placed in a hypobaric oxygen chamber to simulate an altitude of 4000m for simulated plateau culture, and the pressure in the hypobaric oxygen chamber is -39.7kPa;
[0041] The second step is to anesthetize the mice after cultured at high altitude: take the mice out of the hypobaric oxygen chamber after 3 days, anesthetize the mice with an intraperitoneal injection of anesthesia, and fix the anesthetized mice on the brain stereotaxic instrument, and the anesthesia adopts mass fraction 10% chloral hydrate, the anesthetic dose is 0.01mL / kg;
[0042]The third step is to establish the mouse model of plateau craniocerebral injury: sterilize and incise the mouse scalp to expose the bregma and determine the position of the bregma, 1.5 mm in front of the bregma and 1.5 mm to the right side of t...
Embodiment 2
[0048] The application of L-serine in the prevention or treatment of plateau craniocerebral injury, the steps are:
[0049] The first step is to establish a mouse plateau model: C57BL / 6 mice are placed in a hypobaric oxygen chamber to simulate an altitude of 4000m for simulated plateau culture, and the pressure in the hypobaric oxygen chamber is -39.7kPa;
[0050] The second step is to anesthetize the mice after cultured at high altitude: take the mice out of the hypobaric oxygen chamber after 3 days, anesthetize the mice with an intraperitoneal injection of anesthesia, and fix the anesthetized mice on the brain stereotaxic instrument, and the anesthesia adopts mass fraction 10% chloral hydrate, the anesthetic dose is 0.01mL / kg;
[0051] The third step is to establish the mouse model of plateau craniocerebral injury: sterilize and incise the mouse scalp to expose the bregma and determine the position of the bregma, 1.5 mm in front of the bregma and 1.5 mm to the right side of ...
Embodiment 3
[0057] The application of L-serine in the prevention or treatment of plateau craniocerebral injury, the steps are:
[0058] The first step is to establish a mouse plateau model: C57BL / 6 mice are placed in a hypobaric oxygen chamber to simulate an altitude of 4000m for simulated plateau culture, and the pressure in the hypobaric oxygen chamber is -39.7kPa;
[0059] The second step is to anesthetize the mice after cultured at high altitude: take the mice out of the hypobaric oxygen chamber after 3 days, anesthetize the mice with an intraperitoneal injection of anesthesia, and fix the anesthetized mice on the brain stereotaxic instrument, and the anesthesia adopts mass fraction 10% chloral hydrate, the anesthetic dose is 0.01mL / kg;
[0060] The third step is to establish the mouse model of plateau craniocerebral injury: sterilize and incise the mouse scalp to expose the bregma and determine the position of the bregma, 1.5 mm in front of the bregma and 1.5 mm to the right side of ...
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