Compound rhizoma coptidis medicine and application thereof

A technology of Coptis chinensis and medicaments, applied in the direction of suppository delivery, drug combination, drug delivery, etc., can solve the problems of less obvious curative effect, high treatment cost, low cure rate, etc., and achieve good curative effect, strong drug permeability and stable drug effect Effect

Inactive Publication Date: 2019-09-27
高世林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simultaneously, there are many medicines for the treatment of acute and chronic anal sinusitis, proctitis, anorectal neuralgia and rectal inflammatory lesions, but most of them have ineffective curative effect, low cure rate, long course of treatment and high treatment cost.

Method used

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  • Compound rhizoma coptidis medicine and application thereof
  • Compound rhizoma coptidis medicine and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment one: the preparation of compound coptis medicament

[0033] The invention provides a compound coptis medicament. The compound coptis medicament comprises 20%-40% of main drug and 60%-80% of matrix by weight percentage.

[0034] In the present invention, the base may be a suppository base or an ointment base.

[0035] Concretely, the main drug in the present invention includes 14-16% of berberine powder, 3-5% of erythromycin powder, 26-29% of metronidazole powder, 15-18% of Phellodendron phellodendron powder, and Scutellaria baicalensis powder by weight percentage. 17-19% parts, borneol 5-7%, dyclonine powder 2-4%, lidocaine powder 10-13%, ethylparaben 0.3-0.5%.

[0036] Specifically, the suppository base of the present invention is a mixed fatty acid glyceride.

[0037] Specifically, the ointment base of the present invention includes, by weight, 6-9 parts of petrolatum, 4-7 parts of lanolin, 1-2 parts of beeswax, and 1-2 parts of yellow wax.

Embodiment 2

[0038] Embodiment two: the preparation of compound coptis chinensis medicament

[0039] The invention provides a compound coptis medicament. The compound coptis medicament comprises 20% of main drug and 80% of matrix by weight percentage.

[0040] In the present invention, the base may be a suppository base or an ointment base.

[0041] Preferably, the main drug in the present invention includes 14.5% of berberine powder, 4% of erythromycin powder, 27% of metronidazole powder, 16% of Phellodendron Phellodendron powder, 17.5% of Scutellaria baicalensis powder, 6% of borneol, Dacronine powder 3%, lidocaine powder 11.6%, ethyl paraben 0.4%.

[0042] Specifically, the suppository base of the present invention is a mixed fatty acid glyceride.

[0043] Preferably, the ointment base in the present invention comprises 7 parts of vaseline, 5 parts of lanolin, 1 part of beeswax and 1 part of yellow wax in parts by weight.

Embodiment 3

[0044] Embodiment three: the preparation of compound coptis chinensis medicament

[0045] The invention provides a preparation method of compound Coptis chinensis medicament, the specific method steps are as follows:

[0046] (1) The main drug raw materials berberine powder, erythromycin powder, metronidazole powder, cork powder, scutellaria baicalensis powder, borneol, dyclonine powder, lidocaine powder, ethyl paraben, selected to remove impurities Grind the fine powder separately, filter through a No. 6 medicine sieve, and mix in proportion;

[0047] (2) Stir the mixed main drug raw material powder prepared in step (1) with the mixed fatty acid glyceride melted to 60°C, pour it into a suppository mold, open the mold after cooling, take out the prepared suppository and pack it into a box, ready to use;

[0048] (3) Heat medical vaseline, lanolin, beeswax, and yellow wax to form a paste, then add the mixed main drug raw material powder prepared in step (2) into the ointment ...

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Abstract

The invention discloses a compound rhizoma coptidis medicine and application thereof. The compound rhizoma coptidis medicine comprises 20% of main medicine and 80% of bases, wherein the main medicine comprises 14-16% of berberine powder, 3-5% of erythromycin powder, 26-29% of metronidazole powder, 15-18% of cortex phellodendri powder, 17-19% of radix scutellariae powder, 5-7% of borneol, 2-4% of dyclonine powder, 10-13% of lidocaine powder and 0.3-0.5% of ethylparaben; an ointment base comprises 8-10 parts of vaseline, 6-9 parts of lanolin, 1-2 parts of beeswax, 2-4 parts of yellow wax; and a suppository base is mixed fatty acid glyceride. The prepared compound rhizoma coptidis medicine has the effects of anti-inflammation, anti-exudation and pain relief; the prepared suppository has fast absorption for rectal administration of acute and chronic anal sinusitis, proctitis, anorectal neuralgia and rectal inflammatory lesions; and the suppository is slowly dissolved for 24 hours, directly acts on local lesions, has significant treatment effect and strong drug permeability, can directly reach the lesions, and has wide application and popularization values.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular, the invention relates to the technical field of a compound coptis medicament and a preparation method thereof. Background technique [0002] Traditional Chinese medicine treats the symptoms and cures the root cause, has no toxic and side effects, and is quite accepted and selected by people. Chinese medicine has been widely used in the treatment of various diseases, and the effect is good. [0003] Anal sinusitis, also known as anal cryptitis, is an inflammatory lesion in the anal sinus and anal glands. It is an important potential infection focus, and about 85% of anorectal lesions are related to anal sinus infection. In the chronic phase of anal sinusitis, there are no obvious symptoms, but there are often mild pain, swelling or discomfort in the anus, or decreased secretion of anal glands, dry anal canal, and poor defecation. In the acute attack stage, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/06A61K9/02A61K47/14A61K47/44A61P1/00A61P9/14A61P25/02A61K31/235A61K31/045A61K31/167A61K31/4164A61K31/4375A61K31/4453A61K31/7048
CPCA61K9/0031A61K9/02A61K9/06A61K31/045A61K31/167A61K31/235A61K31/4164A61K31/4375A61K31/4453A61K31/7048A61K36/539A61K36/756A61K47/14A61K47/44A61P1/00A61P9/14A61P25/02A61K2300/00
Inventor 高世林
Owner 高世林
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