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Hollow fibre membrane with improved separating efficiency, and production of hollow fibre membrane with improved separating efficiency

A technology of fiber membranes and fiber membrane bundles, applied in the field of hollow fiber membranes for sterilization, hollow fiber membrane filters, and the manufacture of hollow fiber membranes with polysulfone and polyvinylpyrrolidone membrane materials

Active Publication Date: 2019-09-27
FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0031] Previous methods in the production of steam-sterilized polysulfone and polyvinylpyrrolidone-based hollow fiber membranes have been shown to have limited separation power and selectivity due to the sterilization procedure, especially for medium Limited separation capacity of plasma proteins in the molecular weight range

Method used

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  • Hollow fibre membrane with improved separating efficiency, and production of hollow fibre membrane with improved separating efficiency
  • Hollow fibre membrane with improved separating efficiency, and production of hollow fibre membrane with improved separating efficiency
  • Hollow fibre membrane with improved separating efficiency, and production of hollow fibre membrane with improved separating efficiency

Examples

Experimental program
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Effect test

Embodiment 1

[0139] Embodiment 1: the method for purifying hollow fiber membrane filter

[0140] image 3 Schematically depicts the steps comprising rinsing and sterilization for use in the production of hollow fiber membranes according to the invention, respectively hollow fiber membrane filters according to the first, second and third aspects of the invention The first step in the decontamination procedure. image 3 A fluid port 118 of a first chamber 119 of a hollow fiber membrane filter 113 surrounding the interior of the hollow fiber membranes is shown, which is fluidly connected to the connection 101 by a line 109 with a valve 105 . Another fluid port 117 is fluidly connected to connection 102 via line 110 , valve 106 and forms the inlet to a second chamber 120 of hollow fiber membrane filter 113 enclosing the space between the hollow fiber membranes. Another fluid port 114 is in fluid connection with valve 107 and connection 103 via line 111 and forms the inlet to the second chamb...

Embodiment 2

[0149] Example 2: Example implementation of the hollow fiber membrane of the present invention

[0150] A spinning solution consisting of 16 parts by weight of polysulfone (P3500 from Solvay), 4.4 parts by weight of polyvinylpyrrolidone (K82-86 from Ashland) and 79.6 parts by weight of DMAC was stirred, heated to 60°C and degassed so that It is processed into a homogeneous spinning mass. The spinning mass was extruded into strands through an annular spinneret with a center-controlled precipitant consisting of 35% DMAC and 65% water. The precipitating agent is guided within the hollow strands. The temperature of the ring spinneret was 70°C. The extruded strands are led through a precipitation chamber whose atmosphere has a relative humidity of 100%. The height of the sedimentation gap is 200 mm; the residence time of the sedimentation gap is set to 0.4 seconds. The strands were introduced into a precipitation bath consisting of water whose temperature was controlled at 80 °...

Embodiment 3

[0152] Embodiment 3: comparative example

[0153] The same materials as in Example 2 were used. A spinning solution consisting of 16 parts by weight of polysulfone, 4 parts by weight of polyvinylpyrrolidone and 80 parts by weight of DMAC was stirred, heated to 50° C. and degassed in order to process it into a homogeneous spinning mass. The spinning mass was extruded into strands through an annular spinneret with a center controlled precipitant consisting of 54% DMAC and 46% water. The precipitating agent is guided within the hollow strands. The temperature of the ring spinneret was 40°C. The extruded strands were led through a precipitation chamber whose atmosphere had a relative humidity of 30%. The height of the sedimentation gap is 600mm, and the residence time of the sedimentation gap is set to 1.35 seconds. The strands were introduced into a precipitation bath consisting of water whose temperature was controlled at 68 °C and precipitated into hollow fiber membranes. ...

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Abstract

The invention relates to a method for producing a hollow fibre membrane bundle from a plurality of polysulphone-based and PVP-based hollow fibre membranes, involving: providing a spinning solution comprising a material based on polysulphone, particularly polysulphone, a polymer based on vinylpyrrolidone and particularly polyvinylpyrrolidone, an aprotic solvent, particularly dimethylacetamide; providing a coagulation liquid comprising water and an aprotic solvent, particularly dimethylacetamide; coextruding the spinning solution and the coagulation liquid through a concentric annular gap nozzle to form a hollow spun filament, the cavity of the spun filament being filled with coextruded coagulation liquid; passing the spun filament through a precipitation gap; introducing the spun filament into a precipitation bath substantially comprising water, in order to obtain a hollow fibre membrane; passing the hollow fibre membranes through at least one rinsing bath and drying the resulting hollow fibre membrane; arranging the resulting hollow fibre membrane to form a hollow fibre membrane bundle; and treating the hollow fibre membrane bundle with steam.

Description

[0001] subject of the invention [0002] The present invention relates to a hollow fiber membrane comprising polysulfone and polyvinylpyrrolidone-based membrane material, which has improved separation performance, particularly improved ability to separate substances in the middle molecular weight range and improved selectivity with respect to separation of substances in the high and middle molecular weight range. [0003] The present invention further relates to a method for producing a hollow fiber membrane having polysulfone and polyvinylpyrrolidone-based membrane materials. [0004] The present invention also relates to a hollow fiber membrane filter comprising a hollow fiber membrane having uniform permeability. [0005] In particular, the present invention relates to a method for sterilizing hollow fiber membranes of polysulfone and polyvinylpyrrolidone-based membrane materials. [0006] Background of the invention [0007] Hollow fiber membranes are widely used in liquid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D65/02B01D67/00B01D71/44B01D71/68B01D69/02B01D69/08
CPCA61M1/34B01D61/145B01D65/022B01D69/02B01D69/08B01D71/68B01D2053/224B01D2259/4533B01D2321/08B01D2325/20B01D71/441B01D2325/0283B01D2323/081B01D69/088B01D71/62B01D2323/12B01D2325/26
Inventor T·凯勒M·保罗R·桑德尔
Owner FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH