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Polymer drug carrier containing double target ligands

A high-molecular polymer, dual-targeting technology, applied in the field of biomedicine, can solve the problems affecting the targeting ability and interference of drug carriers

Inactive Publication Date: 2019-10-01
JIANGXI SCI & TECH NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a single targeting ligand may be interfered by certain enzymes or exogenous substances in vivo, thus affecting the targeting ability of the drug carrier

Method used

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  • Polymer drug carrier containing double target ligands

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Experimental program
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Effect test

Embodiment 1

[0011] 1. Weigh 10mg FA-F127-PLA block polymer and 3mg PTX and dissolve it in 2ml THF, then disperse the mixture dropwise in 10ml ultrapure water under stirring, then put the suspension into The dialysis bag (MWCO 12-14KDa) was dialyzed in ultrapure water for 5 hours, and the ultrapure water was changed every 1 hour during this period to remove excess THF. After the dialysis was completed, the suspension was centrifuged at 3000 rpm for 5 minutes to remove the precipitate, and then FA-F127-PLA / PTX nanovesicles were obtained. The preparation method of Biotin-F127-PLA / PTX nanovesicles is as described above. The preparation method of Biotin(FA)-F127-PLA / PTX nanovesicles was the same as the above steps except for feeding 5mg Biotin-F127-PLA and 5mg FA-F127-PLA (the above three drug-loaded nanovesicles were prepared aseptically).

[0012] The absorption peak area of ​​PTX was determined by high performance liquid chromatography and the embedding rate of PTX in nanovesicles was cal...

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Abstract

The invention belongs to the field of biological medicine, relates to a polymer drug carrier containing double target ligands, and discloses a preparation method for the drug carrier modified by Tf and FA double ligands and a result generated when the drug carrier is used for researching on the C6 cytotoxicity. The anti-tumor effect of a double-target vesicle preparation containing the Tf and FA ligands is more significant than that of Free PTX and two single-target vesicle preparation.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a polymer drug carrier containing dual targeting ligands. [0002] technical background [0003] At present, cancer has seriously endangered human health, and its treatment mainly includes surgery, radiotherapy and chemotherapy. In chemotherapy methods using anticancer drugs, the anticancer drug release system containing targeting ligands can accurately reach the target for effective release, thereby reducing toxic side effects and pain of patients, so it has become a research hotspot. However, a single targeting ligand may be interfered by certain enzymes or exogenous substances in vivo, thereby affecting the targeting ability of the drug carrier. However, drug carriers modified with dual-targeting ligands can effectively circumvent this problem, and drug carriers modified with dual-targeting ligands have obvious anti-tumor advantages on tumor cells with overexpression of both receptors....

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/34A61K31/337A61K47/54A61K47/64A61P35/00
CPCA61K9/1273A61K31/337A61K47/545A61K47/644A61P35/00
Inventor 熊向源陈相龚妍春李资玲李玉萍
Owner JIANGXI SCI & TECH NORMAL UNIV
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