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Oral composition capable of promoting teeth remineralization

A composition and oral technology, applied in the directions of fluorine compound active ingredients, drug combinations, oral care, etc., to achieve the effects of promoting remineralization, reducing costs, and achieving excellent effects

Inactive Publication Date: 2019-10-11
EZAKI GLICO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been reported that basic peptides and basic proteins have the effect of promoting tooth remineralization

Method used

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  • Oral composition capable of promoting teeth remineralization
  • Oral composition capable of promoting teeth remineralization
  • Oral composition capable of promoting teeth remineralization

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0132] Hereinafter, the present invention will be described in detail based on Examples and the like, but the present invention is not limited to these Examples.

[0133] In addition, in the test example shown below, the phosphorylated sugar calcium salt (POs-Ca) used the product made by Oji Co., Ltd. The phosphorylated sugar calcium salt contained 5.0% by weight of calcium. In addition, the phosphorylated sugar calcium salt mainly includes calcium salts of oligosaccharides whose sugar moieties are 3 to 5 glucose-bonded via α-1,4 bonds, and also contains a small amount of sugar moieties whose sugar moieties are bonded via α-1,4 bonds. A calcium salt of an oligosaccharide bound with seven glucoses. In addition, in this phosphorylated sugar calcium salt, when the sugar moiety is an oligosaccharide composed of 3 to 5 glucoses, one phosphate group is bonded; when the sugar moiety is an oligosaccharide composed of 7 glucoses In this case, two phosphate groups are bonded.

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Abstract

The purpose of the present invention is to provide an oral composition that possesses an excellent teeth remineralization promoting effect and that is capable of effectively promoting teeth remineralization even when retained in the oral cavity for a short period of time. An oral composition in which (A) an organic acid calcium salt, (B) a fluoride, and (C) a basic peptide and / or a basic protein in which 60% or more of the constituent amino acid residues are basic amino acid residues are added in combination is capable of dramatically promoting teeth remineralization as a result of a synergetic effect of these components and is capable of effectively promoting teeth remineralization even when retained in the oral cavity for a short period of time.

Description

technical field [0001] The present invention relates to an oral composition which can promote the remineralization of teeth and is useful for anti-caries use. Background technique [0002] Teeth are made of hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) as the main component. The surface of the tooth is covered with enamel having a dense structure in which aggregates of hexagonal columnar crystals of hydroxyapatite called enamel columns are arranged in a certain direction. The hardness of the tooth is comparable to that of crystal due to this structure, making it the hardest tissue in the living body. However, hydroxyapatite is chemically attacked by acid, and below a critical pH (usually pH 5.5), enamel may dissolve, and calcium and phosphoric acid may be dissolved. [0003] When humans ingest sugar, caries-causing bacteria in the mouth, such as Streptococcus mutans, convert the sugar to produce acid. In addition, by the action of the glucosyltransferase of these bacteria,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A23L33/10A23L33/16A23L33/18A61K8/21A61K8/365A61K8/64A61K31/191A61K31/7024A61K33/16A61K38/04A61K38/16A61P1/02A61Q11/00
CPCA23L33/10A23L33/16A23L33/18A61K8/21A61K8/365A61K8/64A61K33/16A61P1/02A61Q11/00A61K38/02A61K8/60A61K8/88A61K33/06A61K31/702A61K31/198A61K31/4172A61K36/82A61K2300/00A61K8/602
Inventor 田中智子小林隆嗣朝熊弘树
Owner EZAKI GLICO CO LTD
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