Isradipine controlled release tablet and preparation method thereof

A preparation and weight ratio technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of soft material adhesion, high residual organic solvent, long drying time, etc.
CN110327306AActive Publication Date: 2019-10-15DEZHOU DEYAO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DEZHOU DEYAO PHARMA
Publication Date
2019-10-15

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Abstract

The invention provides an isradipine controlled release tablet and a preparation method thereof. The tablet includes a double-layer tablet consisting of a medicine layer and a booster layer, a controlled release semipermeable membrane, drug releasing pores and a moisture-proof coating. The medicine layer includes the main medicine that is isradipine and a carrier, and the carrier mainly includes vinylpyrrolidone and / or vinylpyrrolidone copolymer. The booster layer mainly includes a substance promoting permeation, an insoluble polymer, an osmotic pressure promoter, and the like. The controlledrelease semipermeable membrane mainly includes cellulose acetate, a plasticizer and a pore-foaming agent. Through application of the polymer, the isradipine after being orally taken is released at a controlled speed so that the purpose of maintaining 24 hours of medicine release only by one time of medicine taking each day is achieved, the blood medicine concentration is stabilized, and clinical treatment effects of the medicine are improved.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a single-chamber double-layer osmotic pump-type controlled-release preparation containing the active drug isradipine and a preparation method thereof, which enables isradipine to release the drug at a controlled rate in the gastrointestinal tract, Realize stable blood drug concentration in the body and improve clinical treatment effect. Background technique

[0002] Isradipine (also known as: Isradipine), chemical name: isopropylmethyl (±)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl -3,6-Pyridinedicarboxylate. Isradipine is a new type of dihydropyridine calcium channel blocker, like other dihydropyridine drugs, by blocking the influx of transmembrane calcium ions, it can effectively and selectively inhibit the contraction caused by depolarization in the It plays a role in cardiac muscle and vascular smooth muscle, has high selectivity of blood vessels, and can relax...

Claims

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