Flos chrysanthemi indici extract and preparation method thereof and application of flos chrysanthemi indici extract to preparation of drugs for treatment of nasopharyngeal carcinoma

A wild chrysanthemum extract, nasopharyngeal cancer technology, applied in the direction of drug combination, organic chemical methods, antineoplastic drugs, etc., can solve the problems of toxicity, affecting the quality of life, local recurrence of nasopharyngeal cancer cells, etc., and achieve safe and reliable ingredients Effect

Active Publication Date: 2019-10-18
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, radiotherapy and chemotherapy will bring many side effects to patients, such as headache, dry mouth and fever, heart and kidney toxicity, etc., seriously affecting people's quality of life
Moreover, the treatment of nasopharyngeal carcinoma often leads to local recurrence and the phenomenon of distant metastasis of nasopharyngeal carcinoma cells

Method used

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  • Flos chrysanthemi indici extract and preparation method thereof and application of flos chrysanthemi indici extract to preparation of drugs for treatment of nasopharyngeal carcinoma
  • Flos chrysanthemi indici extract and preparation method thereof and application of flos chrysanthemi indici extract to preparation of drugs for treatment of nasopharyngeal carcinoma
  • Flos chrysanthemi indici extract and preparation method thereof and application of flos chrysanthemi indici extract to preparation of drugs for treatment of nasopharyngeal carcinoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The method for preparing compound formula (I) and formula (II) from wild chrysanthemum (Chrysanthemum indicum):

[0038] 1. Chrysanthemum indicum (Chrysanthemum indicum) aerial part (6kg), dried, pulverized, leached four times with 95% ethanol water at room temperature, each time for 72 hours, combined concentrated solutions to obtain crude extract (700g), washed with ethyl acetate Extraction, the ethyl acetate (300g) part was directly subjected to silica gel column chromatography (2500g, 200-300 mesh, 7.0×100cm), petroleum ether / ethyl acetate gradient elution (10:0, 9:1, 4:1, 2:1, 0:1), collect one portion per 500mL, and combine the same portion for TLC detection to obtain 5 fractions Fr.A-E in total.

[0039] 2. Part of Fr.D (30g) passed C 18Three fractions of Fr.D1-D3 were obtained by reverse column separation. Among them, the Fr.D1 component was passed through a silica gel column and eluted with petroleum ether-ethyl acetate (4:1-1:1) to obtain 5 fractions Fr.D1a-...

Embodiment 2

[0079] Prepare formula (I) and formula (II) by the method of Example 1, add water for injection as usual, fine filter, potting and sterilizing to make injection.

Embodiment 3

[0081] According to the method of Example 1, formula (I) and formula (II) were first prepared, dissolved in sterile water for injection, stirred to dissolve, and filtered with a sterile suction filter funnel. Then aseptically finely filtered, divided into 2 ampoules, freeze-dried at low temperature, and aseptically melt-sealed to obtain a powder injection.

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Abstract

The invention provides a flos chrysanthemi indici extract and new application of the flos chrysanthemi indici extract to preparation of drugs for prevention and treatment of nasopharyngeal carcinoma,and further provides a preparation method of the flos chrysanthemi indici extract. The provided flos chrysanthemi indici extract has the obvious effect on inhibiting the growth of nasopharyngeal carcinoma cells, the nasopharyngeal carcinoma cells HONE-1 can be blocked in the G2/M period, and apoptosis of the nasopharyngeal carcinoma cells can be induced; and a compound provided by the flos chrysanthemi indici extract comes from plants, is safe and reliable, has the good effect of inhibiting nasopharyngeal carcinoma, and can be applied to preparation of the drugs for treatment of nasopharyngealcarcinoma.

Description

technical field [0001] The invention relates to the technical field of active ingredients of Chinese herbal medicines and medicines, and more specifically relates to a wild chrysanthemum extract, a preparation method thereof and an application in preparation of medicines for treating nasopharyngeal carcinoma. Background technique [0002] Nasopharyngeal carcinoma (NPC) is a malignant tumor with high incidence in South China, accounting for about 18% of the national cancer population. The formation of nasopharyngeal carcinoma may be related to Epstein-Barr Virus (EBV) infection, environmental factors and genetic factors. The clinical manifestations are headache, hearing loss, nasal congestion and blood in the nasal discharge. The treatment of nasopharyngeal carcinoma is mainly based on radiotherapy, often supplemented by combined chemotherapy with chemotherapy. Broad-spectrum antineoplastic drugs are commonly used in chemotherapy, such as 5-fluorouracil, cisplatin and gemcit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/10C07D307/93A61P35/00
CPCC07D493/10C07D307/93A61P35/00C07B2200/13
Inventor 顾琼徐峻程燕芳
Owner SUN YAT SEN UNIV
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