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Compositions and methods for treating, ameliorating and preventing h. pylori infections

A Helicobacter pylori, individual technology, applied in the field of infectious diseases and drugs, can solve problems such as rising clarithromycin resistance

Pending Publication Date: 2019-10-22
CENT FOR DIGESTIVE DISEASES PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, rising resistance to clarithromycin has terminated the clinical use of this combination in many parts of the world

Method used

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  • Compositions and methods for treating, ameliorating and preventing h. pylori infections
  • Compositions and methods for treating, ameliorating and preventing h. pylori infections
  • Compositions and methods for treating, ameliorating and preventing h. pylori infections

Examples

Experimental program
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Effect test

Embodiment

[0554] A 47-year-old man, allergic to penicillin, was referred after five different therapies had failed to eradicate H. pylori and he remained symptomatic. To better improve eradication and biofilm dissolution, he pretreated with Bifidobacterium infantum three times a day for 4 weeks, and this was continued during antibiotic treatment for the next 10 days. Antibiotic therapy included [all × 3 per day] vonoprazan 20 mg; metronidazole 400 mg; bismuth subsalicylate 300 mg; tetracycline HCl 400 mg; When retested by urea breath test 4 weeks after discontinuation of treatment, the test was negative, showing bacterial eradication.

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Abstract

Provided are methods for treating, ameliorating, reversing and / or preventing a Helicobacter pylori (H. pylori) infection in an individual in need thereof, comprising: administering to the individual in need thereof a therapeutic combination comprising: (a) a composition comprising or consisting of: vonoprazan or a vonoprazan fumarate, or a 5- (2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine monofumarate, or a 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methyl-methanamine fumarate), optionally TAKECABTM; and (b) an antimicrobial or antibiotic drug or composition.

Description

technical field [0001] The present invention relates generally to infectious diseases and medicines. In an alternative embodiment, there is provided a combination of therapeutic agents for treating, alleviating, reversing and / or preventing (as prophylaxis) Helicobacter pylori (H. pylori) infection in an individual in need thereof, the combination comprising manufactured Products and kits and methods. Background technique [0002] The history of H. pylori eradication dates back to 1984 when the first triple therapy was developed in Australia by Borody of the Center for Digestive Diseases. It consists of bismuth, tetracycline, and metronidazole. Its long-term effects were reported in 1989, and it was dispensed to patients on prescriptions written by most physicians in combination as a single prescription until a commercial product known as Helidac became available in several countries. Since then, a number of triple therapies have been described, the most common of which is...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K31/43A61K31/7048A61K31/4164A61K31/438A61K31/5383A61K31/496A61K31/4725A61K31/24A61K31/422A61K31/65A61K31/29A61K31/04A61P1/04
CPCA61P31/04A61K31/43A61K31/4164A61K31/65A61K31/454A61K31/60A61K31/4439A61K33/245A61K35/745A61K2300/00A61K31/7048A61K31/5383A61K31/4709A61K31/4178A61K31/422A61K31/438A61P1/04A61K31/426A61K31/424A61K33/00
Inventor 托马斯·朱利叶斯·波洛迪
Owner CENT FOR DIGESTIVE DISEASES PTY LTD