Application of succinylation-related preparations for regulation of mitochondrion OCR

A succinylation, mitochondrial technology, applied in the biological field, can solve problems such as unclear effect
CN110403940APending Publication Date: 2019-11-05SHANDONG PROVINCIAL HOSPITAL
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Patent Information

Authority / Receiving Office
CN Ā· China
Current Assignee / Owner
SHANDONG PROVINCIAL HOSPITAL
Publication Date
2019-11-05

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Abstract

The invention discloses application of succinylation-related preparations for the regulation of mitochondrion OCR. According to the application of the succinylation-related preparations for the regulation of the mitochondrion OCR, mitochondrion oxygen consumption (p<average>is less than 0.05) is significantly reduced after treatment of human thyroid epithelial cells with palmitic acid, while the change of the mitochondrion oxygen consumption(p<average>is less than 0.05) is on the contrary after treatment of the human thyroid epithelial cells with palmitic acid and a desuccinylation inhibitor.The result of further detection of succinylation IDH2 (isocitrate dehydrogenase 2) shows that the result is achieved by regulating the succinylation of IDH2, that is, the succinylation of the IDH2 isreduced, mitochondrion OCR is reduced, and the desuccinylation inhibitor is involved in increasing or restoring succinylation of the IDH2, and the mitochondrion OCR is enabled to be increased or restored. The application of the succinylation-related preparations for the regulation of the mitochondria OCR provides a novel drug target for the treatment of congenital hypothyroidism.
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Description

technical field

[0001] The invention relates to the field of biotechnology, and relates to the application of succinylation-related preparations in regulating mitochondrial OCR, in particular to the use of desuccinylation inhibitors in improving mitochondrial OCR disorders. Background technique

[0002] Thyroid hormones are synthesized and secreted by the thyroid gland and play a vital role in normal human development, differentiation and metabolism. Disorders of thyroid hormones can lead to a variety of thyroid diseases.

[0003] Hypothyroidism is a common and serious disorder of the endocrine system. Thyroxine deficiency refers to low serum total thyroxine (TT4), which often leads to elevated thyroid-stimulating hormone (TSH) concentrations through negative feedback on the hypothalamus-pituitary-thyroid axis. Primary hypothyroidism is caused by the dysfunction of the thyroid gland itself and is the main cause of hypothyroidism. The onset of hypothyroidism in adults is o...

Claims

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