A kind of injectable hydrogel material and its preparation method, application

A technology of gel material and injection water, which is used in the preparation of X-ray contrast agents, pharmaceutical formulations, preparations for in vivo tests, etc. The problems of poor biodegradability and poor biodegradability, and slow coagulation of injectable hydrogels can achieve the effect of enhancing in vivo traceability, high integrity and adjustability, and good resistance to exercise fatigue.

Active Publication Date: 2021-03-09
杭州碧泰生物医疗科技有限责任公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In order to overcome the problems of slow coagulation, low strength, poor biocompatibility and biodegradability of the existing injectable hydrogel, which is not conducive to the fixed-point molding of the gel after injection and long-term exercise tolerance, the present invention provides a An injectable hydrogel material with good exercise tolerance, high biocompatibility and biodegradability, multimodal imaging and controllable degradation functions

Method used

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  • A kind of injectable hydrogel material and its preparation method, application
  • A kind of injectable hydrogel material and its preparation method, application
  • A kind of injectable hydrogel material and its preparation method, application

Examples

Experimental program
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Effect test

Embodiment 1

[0039] (1) Accurately weigh 10.0g chitosan and 10g sodium hydroxide in a three-necked flask, add 100mL isopropanol solvent, and swell at 50°C for 3 hours; accurately weigh 10.0g monochloroacetic acid and dissolve it in 20mL isopropanol middle. Slowly add chloroacetic acid solution dropwise into chitosan lye to react for 12 hours; pour 200mL of absolute ethanol to wash the product, filter and dry to obtain carboxymethyl chitosan;

[0040] (2) Accurately weigh 1.0 g of guar gum, dissolve it in 100 mL of water, add 10 mL of sodium periodate solution (0.1 g / mL) dropwise in the dark at room temperature, and react for 2 h. Centrifuge to remove slag, precipitate the product with ethanol, and dry to obtain bisaldehyde guar gum;

[0041] (3) Measure 10 mL of iohexol injection, add 1 mL of sodium periodate solution (0.1 g / mL) dropwise in the dark at room temperature and react for 1 hour; separate and purify by column chromatography to obtain an aldylated iohexol solution;

[0042] (4)...

Embodiment 2- Embodiment 5

[0048] The difference between Example 2-Example 5 and Example 1 is that in step (5), the formulation of component B is different, see Table 1, and the rest of the processes are identical.

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Abstract

The invention relates to the technical field of medical polymer materials, in order to solve the problem of slow coagulation, low strength, poor biocompatibility and biodegradability of the existing injectable hydrogel, which is not conducive to fixed-point molding of the gel after injection and long-term exercise tolerance To solve the problem of sex, an injectable hydrogel material is provided, the injectable hydrogel material is generated in situ by equal-volume injection of component A and component B using a double injection process; the component A is carboxylated Methyl chitosan, the B component is obtained by reacting dialdehyde polysaccharide with auxiliary cross-linking agent and formaldehyde contrast agent. The injectable hydrogel material of the present invention has good motion tolerance, meets the requirements of biocompatibility and biodegradability, and also has the functions of multi-modal development and controllable degradation, achieving integrated protection, tracing, and customization It has a broad application prospect in the field of diagnosis and treatment integration.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to an injectable hydrogel material and its preparation method and application. Background technique [0002] The integration of diagnosis and treatment is an emerging medical technology that organically combines the diagnosis and treatment of diseases. Through the combination of diagnostic components and therapeutic components, it is expected to realize accurate and timely treatment while detecting diseases to avoid further deterioration. This is especially important for cancer. Cancer treatments generally include surgery, chemotherapy, and radiotherapy. Chemotherapy and radiotherapy have serious side effects, and tumor tissue is difficult to identify during surgery. Therefore, targeted treatment of the lesion during the diagnosis period is expected to give timely and effective treatment in the early detection and reduce the chance of deterioration and spread. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K49/12A61K49/18A61K49/22A61K9/06A61K47/36C08B37/08C08J3/075C08L5/08C08L5/00
CPCA61K9/0024A61K9/06A61K47/36A61K49/0002A61K49/0457A61K49/12A61K49/1803A61K49/222C08B37/003C08J3/075C08J2305/08C08J2405/00
Inventor 王旭陈思王成严森祥吴凌云
Owner 杭州碧泰生物医疗科技有限责任公司
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