Transdermal precision drug-delivery device based on microneedle-type ionophoresis device and preparation method thereof

A drug delivery device and microneedle technology, applied in the field of transdermal precise drug delivery device and its preparation, can solve the problems that macromolecular protein hormone drugs are easily decomposed, achieve release and termination, precisely regulate blood sugar, improve Effect of transdermal diffusion rate

Inactive Publication Date: 2019-11-05
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, frequent injections and infusions will bring patients pain and risk of infection caused by bacteria, viruses, etc., inflammation and related complications
In addition, insulin cannot enter the body through the gastrointestinal tract after oral admi

Method used

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  • Transdermal precision drug-delivery device based on microneedle-type ionophoresis device and preparation method thereof
  • Transdermal precision drug-delivery device based on microneedle-type ionophoresis device and preparation method thereof
  • Transdermal precision drug-delivery device based on microneedle-type ionophoresis device and preparation method thereof

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Embodiment Construction

[0034] Such as figure 1 , figure 2 As shown, a transdermal precise drug delivery device based on a microneedle ionophoretic device according to the present invention includes a composite microneedle 10, a DC power supply 30 and a skin electrode sheet 40 connected sequentially through a wire 20. The composite microneedle 10 includes a microneedle patch 11 and an adjustable drug-loading substrate 12, and the microneedle patch 11 is formed by crosslinking polyethylene glycol-crosslinked polymethylvinyl ether-maleic acid with Hydrogel microneedles in grid gaps, the drug-loaded substrate 12 includes a composite hydrogel 121 composed of photocured polyethylene glycol diacrylate (PEGDA) 1211 and insulin 1212, and the composite hydrogel The back of the adhesive 121 is provided with a microneedle electrode sheet 13, and the skin-covered electrode sheet 40 and the microneedle electrode sheet 13 are both platinum electrodes, which have good electrical conductivity and high chemical sta...

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Abstract

The invention belongs to the technical field of medical drug delivery devices, and specifically discloses a transdermal precision drug-delivery device based on a microneedle-type ionophoresis device.The transdermal precision drug-delivery device comprises a composite microneedle, a DC power source and a skin electrode sheet which are sequentially connected by wires, and the composite microneedlecomprises a microneedle patch and a controllableg drug-loading substrate. The microneedle patch is a hydrogel microneedle with a grid gap formed by crosslinking polyethylene glycol-crosslinked polyvinyl methyl ether-maleic acid. The drug-loading substrate comprises a photo-cured polyethylene glycol diacrylate (PEGDA) and a composite hydrogel coated with insulin, and a back surface of the compositehydrogel is provided with a microneedle electrode sheet. The drug delivery device efficiently realizes macro-molecule transdermal administration such as insulin, and greatly improves the transdermaldiffusion rate of insulin by ion electrophoresis. The device can achieve more precise and controllable administration by changing the voltage, current and time of ion electrophoresis, realizes intelligent release and termination of insulin, and more accurately regulate blood sugar.

Description

technical field [0001] The invention belongs to the technical field of medical drug delivery devices, in particular to a transdermal precise drug delivery device based on a microneedle ionophoretic device and a preparation method thereof. Background technique [0002] In the prior art, diabetes is a metabolic disease characterized by the failure of the blood sugar level regulation mechanism, and it is the third chronic non-communicable disease that endangers human health after cardiovascular and cerebrovascular diseases and tumors. The latest analysis report published by the International Diabetes Federation shows that the number of adults with diabetes (20-79 years old) has increased from 151 million in 2000 to 425 million in 2017, an increase of nearly 2 times, and more than 5.1 million people die directly or indirectly from diabetes every year. Diabetes, and it is increasing every year. It is estimated that by 2045, there will be more than 600 million diabetic patients, ...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61N1/30A61K9/70A61K47/14A61K38/28A61P3/10
CPCA61K9/0021A61K38/28A61K47/14A61M37/0015A61M2037/0007A61M2037/0023A61M2037/0053A61N1/30A61P3/10
Inventor 谢曦李湘凌胡宁何根陈惠琄杭天黄新烁杨成端
Owner SUN YAT SEN UNIV
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