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Application of C6ORF106 antibody detection reagent in fabrication of lung cancer screening kit

A technology of autoantibodies and kits, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem of no lung cancer and other problems, achieve good application prospects, low patient harm, and effective screening effects

Active Publication Date: 2019-11-05
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no related reports on C6ORF106 protein autoantibodies, and there is no prior art related to lung cancer

Method used

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  • Application of C6ORF106 antibody detection reagent in fabrication of lung cancer screening kit
  • Application of C6ORF106 antibody detection reagent in fabrication of lung cancer screening kit
  • Application of C6ORF106 antibody detection reagent in fabrication of lung cancer screening kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Relationship between C6ORF106 autoantibodies in plasma and lung cancer

[0026] 1. Clinical data

[0027] Select 30 cases of lung cancer patients and 30 cases of healthy controls. The basic information is as follows:

[0028] Basic Information lung cancer patients healthy control number of people 30 30 age 58±10.5 42±8.9 male ratio 20(66.7％) 13(46.7％)

[0029] 2. Detection principle

[0030] HuProt TM The C6ORF106 protein is immobilized on the human protein custom chip. After incubation with serum, C6ORF106 autoantibodies (mainly including IgG, IgM antibodies, and some other types of antibodies) in the serum will bind to it, and the unbound antibodies and other proteins will be removed by washing. Then use anti-human IgM fluorescently labeled secondary antibody (cy5-labeled, red) and anti-human IgG fluorescent secondary antibody (cy3-labeled, green) to detect, and read the signal through a fluorescent scanner. The stre...

Embodiment 2

[0047] Embodiment 2 Composition of the detection kit of the present invention and its method of use

[0048] 1. Kit composition

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Abstract

The invention relates to the field of in-vitro diagnostic reagent, in particular to application of a C6ORF106 antibody detection reagent in fabrication of a lung cancer screening kit. The antibody level of C6ORF106 protein in serum of a lung cancer patient is initially found out to be remarkably higher than that of a health person. The reagent for detecting the C6ORF106 protein antibody is used for fabricating the lung cancer screening kit, and effective screening of lung cancer can be achieved.

Description

technical field [0001] The invention relates to the field of in vitro diagnostic reagents, in particular to the use of C6ORF106 autoantibody detection reagents in the preparation of lung cancer screening kits. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world. Its morbidity and mortality are increasing year by year. Currently, the incidence rate ranks first in the world, which seriously threatens human health and life. [0003] Lung cancer is a disease that is good at concealment. It often shows clinical symptoms when the disease develops to an advanced stage. 70-80% of lung cancer patients are already in the middle or late stage when they are diagnosed with lung cancer symptoms. The best cure time, five-year survival rate is low. For patients with early lung cancer, timely treatment can greatly improve the 5-year survival rate and quality of life of the patients. Therefore, early diagnosis and effective screening of lung can...

Claims

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Application Information

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IPC IPC(8): G01N33/574
CPCG01N33/57423
Inventor 晁宁宁张立
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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