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Blue silk sericin lyophilized ball and preparation method thereof

A technology of sericin and freeze-drying, which is applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of easy breakage, easy shrinkage, poor forming effect of freeze-dried balls, etc.

Inactive Publication Date: 2019-11-12
广州市玉鑫化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a blue silk gum protein freeze-dried ball and its preparation method, which solves the problems of poor molding effect, easy shrinkage, easy breakage, and single color of the existing freeze-dried balls.

Method used

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  • Blue silk sericin lyophilized ball and preparation method thereof
  • Blue silk sericin lyophilized ball and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A kind of blue sericin freeze-dried ball, the formula is as follows according to mass percentage: 10% of sericin, 2% of sodium hyaluronate (1 million daltons), 25% of mannitol, 10% of pullulan , tripeptide-1 copper 0.3%, sterile deionized water added to 100%.

[0018] The preparation method of the present invention comprises the following steps:

[0019] (1) Weigh sodium hyaluronate, mannitol, pullulan plus sterile deionized water, heat to 70-80°C, and prepare a uniform and transparent solution;

[0020] (2) When the temperature of the solution in step 1 is lowered to 25-35°C, add sericin and tripeptide-1 copper, and stir evenly;

[0021] (3) Aseptically freeze the dosing solution obtained in step 2 in a GMP production environment, and mold it into a ball (1 cm in diameter);

[0022] (4) Transfer the ice balls obtained in step 3 to a pre-sterilized and pre-frozen freeze dryer at -40--50°C, and directly freeze-dry for 20-40 hours;

[0023] (5) Freeze-drying is complet...

Embodiment 2

[0025] A kind of blue sericin freeze-dried ball, formula is as follows according to mass percentage: 25% of sericin, 2% of sodium hyaluronate (1.1 million Daltons), 25% of mannitol, 10% of pullulan , tripeptide-1 copper 0.3%, sterile deionized water added to 100%.

[0026] The preparation method of the present invention comprises the following steps:

[0027] (1) Weigh sodium hyaluronate, mannitol, pullulan plus sterile deionized water, heat to 70-80°C, and prepare a uniform and transparent solution;

[0028] (2) When the temperature of the solution in step 1 is lowered to 25-35°C, add sericin and tripeptide-1 copper, and stir evenly;

[0029] (3) Aseptically freeze the dosing solution obtained in step 2 in a GMP production environment, and mold it into a ball (1 cm in diameter);

[0030] (4) Transfer the ice balls obtained in step 3 to a pre-sterilized and pre-frozen freeze dryer at -40--50°C, and directly freeze-dry for 20-40 hours;

[0031] (5) Freeze-drying is completed...

Embodiment 3

[0033] A kind of blue sericin freeze-dried ball, formula is as follows according to mass percentage: 25% of silk sericin, 2% of sodium hyaluronate (1.2 million daltons), 25% of mannitol, 10% of pullulan , tripeptide-1 copper 0.6%, sterile deionized water added to 100%.

[0034] The preparation method of the present invention comprises the following steps:

[0035] (1) Weigh sodium hyaluronate, mannitol, pullulan plus sterile deionized water, heat to 70-80°C, and prepare a uniform and transparent solution;

[0036] (2) When the temperature of the solution in step 1 is lowered to 25-35°C, add sericin and tripeptide-1 copper, and stir evenly;

[0037] (3) Aseptically freeze the dosing solution obtained in step 2 in a GMP production environment, and mold it into a ball (1 cm in diameter);

[0038] (4) Transfer the ice balls obtained in step 3 to a pre-sterilized and pre-frozen freeze dryer at -40--50°C, and directly freeze-dry for 20-40 hours;

[0039] (5) Freeze-drying is comp...

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Abstract

The invention relates to a blue silk sericin lyophilized ball, which comprises the following components by mass percentage: 10%-30% of silk sericin, 0.1%-10%of sodium hyaluronate (100-1.4 million Daltons), 25%-35% of mannitol, 10%-20% of pullulan polysaccharide, and 0.2%-1.5% of tripeptide-1 copper, and sterile deionized water is added to 100%. A preparation method comprises the following steps: (1) weighing sodium hyaluronate, mannitol, pullulan polysaccharide and the sterile deionized water, and heating the materials to 70-80 DEG C to prepare a uniform transparent solution; (2) when the temperature of the solution in step 1 is reduced to 25-35 DEG C, adding silk sericin and tripeptide-1 copper, and uniformly stirring the materials; (3) freezing a solution aseptically and shaping the material into balls; and (4) transferring the ice balls to a lyophilizer that is pre-sterilized and frozen to 40-50 DEG C. The blue silk sericin lyophilized ball solves the problems of poor molding effect, easy shrinkage, easy fragmentation, and single color of the existing lyophilized balls.

Description

technical field [0001] The invention relates to cosmetics, in particular to a blue sericin freeze-dried ball and a preparation method thereof. Background technique [0002] The previously commercially available freeze-dried balls have poor shape, are easy to shrink and break, and are not easy to store. The present invention uses sericin as the main freeze-drying framework, and after freeze-drying, it can form a porous, easy-to-rehydrate and dissolve, stable structure, and at the same time, mannitol, pullulan and sodium hyaluronate are added to stabilize the shape, so that Freeze-dried balls are not easily deformed during transportation and storage. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a blue silk gum protein freeze-dried ball and its preparation method, which can solve the problems of poor molding effect, easy shrinkage, easy breakage and single color of the existing freeze-dried ball. [0004] In or...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/34A61K8/64A61K8/73A61Q19/00
CPCA61K8/64A61K8/735A61K8/345A61K8/73A61K8/025A61Q19/00
Inventor 苏焕鑫林泽森黄勇付国海
Owner 广州市玉鑫化妆品有限公司
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