Purification method of potassium dehydroandrograpolide succinate

Abstract

The invention provides a purification method of potassium dehydroandrograpolide succinate. Through precisely controlling the concentration and dosage of ethanol, impurity generation is reduced. The method, compared with the prior art, is more favorable to industrial scale-up, has lower requirements on equipment, can achieve whole-process sealed production, can reduce the risk of microbial contamination, guarantees the quality of products, and has practical promotion and application value.

Description

technical field [0001] The invention relates to a purification method of Chuanhuning. Background technique [0002] Chuanhuning is the potassium salt of andrographolide disuccinate half ester obtained from the reaction of andrographolide extracted from the leaves of the traditional Chinese medicine Andrographis paniculata and potassium succinate anhydride. It is a white to light yellow solid. It has antiviral, antipyretic and anti-inflammatory effects. Chuanhuning has been listed as one of the first batch of Chinese patent medicines necessary for first aid in Chinese medicine hospitals because of its remarkable curative effect and low toxicity. With the widespread use of the drug in clinical practice, the reports of adverse reactions are increasing year by year, mainly because the purity is not high enough. [0003] In order to improve the purity of Chuanhuning, reduce the adverse reactions of Chuanhuning, and improve product quality, the patent CN1357546A reports that the...

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Problems solved by technology

With the widespread use of the drug in clinical practice, its adverse reaction reports are increasing year by year, mainly because the purity is not high enough

[0003] In order to improve the purity of Chuanhuning, reduce the adverse reactions of Chuanhuning, and improve product quality, the patent CN1357546A reports that the quality of the product made from the raw material of Chuanhuning through ultrafiltration is obviously improved. state, and the temperature control of the ultrafiltration operation is difficult; secondly, the ultrafiltration membrane of this method needs to be regenerated after filtration, and a large amount of solvent is required to elute the intercepted substances in the membrane to ensure that the membrane can be used again. The interception efficiency decreases, the equipment loss is large, the production cost is high, and industrialization is difficult

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