Unlock instant, AI-driven research and patent intelligence for your innovation.

Absorbable bone wax and preparation method thereof

A bone wax and bone repair technology, applied in the field of biomedical engineering materials, can solve the problems of destroying surrounding tissue, unable to repair bone tissue, affecting bone regrowth, etc., achieving strong antibacterial and bacteriostatic effects, reducing inflammation, and inducing bone The effect of hyperplasia

Inactive Publication Date: 2019-11-29
BEOGENE BIOTECH GUANGZHOU
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this type of bone wax is that the wax has poor adhesion and high brittleness at room temperature.
The most common bone wax is non-absorbable by the human body. When this bone wax is used in surgery, it will remain in the application site for a long time, which can easily cause infection and inflammation, damage surrounding tissues, and affect bone regeneration.
At the same time, the application principle of this type of bone wax is relatively simple. It uses physical sealing to block the blood capillaries in the bone marrow. When the amount of bleeding is large, there is a possibility that it cannot be blocked.
In addition, there are often bone defects in trauma or surgery. At the same time, it is easy to cause infection and inflammation during trauma and surgery, destroy surrounding tissues, and affect bone regeneration. However, traditional bone wax cannot effectively treat bone defects. Repair of defective bone tissue

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Absorbable bone wax and preparation method thereof
  • Absorbable bone wax and preparation method thereof
  • Absorbable bone wax and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] In some embodiments, the present invention provides a method for preparing hemostatic starch microspheres, comprising the steps of:

[0045] Weigh a certain amount of soluble starch, add an appropriate amount of purified water, mix thoroughly, adjust the pH with anhydrous sodium carbonate, heat and stir on a magnetic stirrer, gelatinize until transparent, and cool for later use. Weigh a certain amount of cross-linking agent and put it in another beaker, add an appropriate amount of purified water, stir and dissolve on a magnetic stirrer, pour it into the gelatinized starch solution after dissolution, stir evenly, and set aside. Add an appropriate amount of soybean oil into the three-necked flask and then add the emulsifier Span80, put it into a constant temperature water bath and heat it to 60°C to completely dissolve the Span80, then cool it down to 45°C and add the prepared starch solution slowly under mechanical stirring. When the starch solution is added dropwise, r...

Embodiment 1

[0084] The preparation of embodiment 1 hemostatic starch microspheres

[0085] Weigh 24g of soluble starch, add an appropriate amount of purified water and mix thoroughly to prepare 8wt% starch solution, adjust pH≧10 with anhydrous sodium carbonate, heat to 60°C on a magnetic stirrer, and stir at a speed of 400r / min , gelatinized until transparent, cooled for later use. Weigh 2.4g of the cross-linking agent and put it in another beaker, add an appropriate amount of purified water, stir and dissolve on a magnetic stirrer, pour it into the gelatinized starch solution after dissolution, stir evenly, and set aside. According to the water / oil ratio of 1 / 2, add 600ml of soybean oil into the three-necked flask and then add 5.4g of emulsifier Span80, put it in a constant temperature water bath and heat it to 60°C to completely dissolve Span80, then cool it down to 45°C under mechanical stirring , Slowly add the prepared starch solution. When the starch solution is added dropwise, re...

Embodiment 2

[0087] Preparation of Example 2 β-tricalcium phosphate (β-TCP) bone repair material

[0088] Weigh a certain amount of Ca(NO 3 ) 2 , and dissolve it in a beaker containing deionized water to prepare a 0.5mol / L solution; then weigh a certain amount of (NH 4 ) 2 HPO 4 and dissolve it in a beaker containing deionized water to prepare a 0.5mol / L solution; add an appropriate amount of SDS to Ca(NO 3 ) 2 In the solution, under 400~600rpm mechanical stirring, according to Ca(NO 3 ) 2 with (NH 4 ) 2 HPO 4 The molar ratio of 3:1 was added dropwise (NH 4 ) 2 HPO 4 solution; in dropwise addition (NH 4 ) 2 HPO 4 In the process of solution, add a certain amount of ammoniacal liquor, make whole system keep pH ≥ 10 in reaction process; 4 ) 2 HPO 4 After the solution was added dropwise, continue to react for 2 hours under mechanical stirring, and then let the precipitation stand for one night; then use a Buchner funnel to carry out suction filtration, and then alternately wa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses absorbable bone wax and a preparation method thereof. The method comprises the following steps: 1) mixing a polyoxypropylene polyoxyethylene block copolymer and a polyoxypropylene polyoxyethylene random copolymer and stirring uniformly under the heating condition to obtain a liquid mixture; 2) adding hemostatic starch microspheres into the liquid mixture obtained in the Step 1) under the condition of keeping mechanical stirring and heating so as to obtain a uniformly-mixed liquid; and 3) adding a bone repair material as described in the claim 1 or 2 into the uniformly-mixed liquid obtained in the Step (2), uniformly mixing, pouring the mixture into a mold or a split charging bottle, standing at normal temperature, curing and molding to obtain the absorbable bone wax. By improving main components of the bone wax, bioavailability of the bone wax is improved, degradability of the bone wax is enhanced, and inflammation caused by retention of the bone wax is reduced;the effect of rapid hemostasis can be achieved, and the single hemostasis method that traditional bone wax only depends on physical plugging is changed.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering materials, in particular to an absorbable bone wax and a preparation method thereof. Background technique [0002] Bone bleeding occurs during many traumas and operations, and therefore, it is necessary to control the bleeding of the bone or to stop the bleeding of the bone. Bone wax is a bone hemostatic material used to control localized bone bleeding during surgery by applying bone blood to the cut surface. Most of the bone waxes currently used in surgery are prepared from beeswax by mixing beeswax with water-insoluble hydrocarbons and vegetable oils. The disadvantage of this type of bone wax is that the bone wax has poor adhesion and high brittleness at room temperature. However, the widely used traditional bone wax can cause not only chronic inflammation but also foreign body reactions, reduce bacterial gaps leading to non-union, increase the risk of bone infection, and inhibi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/04A61L24/06A61L24/00A61L24/02
CPCA61L27/18A61L27/12A61L27/047A61L24/06A61L24/0042A61L24/0015A61L24/02A61L2430/02A61L2300/104A61L2300/404A61L2400/04C08L79/02C08L87/005A61L24/0084A61L24/046A61L2400/12A61L2300/204C08B31/003C08L3/02C08L71/02
Inventor 蓝咏刘玉陈宇
Owner BEOGENE BIOTECH GUANGZHOU