Self-healing injectable hydrogel dressing for restoring diabetic wound as well as preparation method and application thereof

A technology for wound repair and water injection, applied in the field of biomedical materials and regenerative medicine, it can solve the problems of slow healing, easy wound infection, and difficult vascularization, and achieve the effects of easy access, accelerated healing, and reduced residual

Active Publication Date: 2019-01-01
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been many hydrogel wound dressings in clinical practice, such as 3M Tegaderm, Kangweier, polyurethane gel, etc., they are relatively expensive and have not solved the key problems of easy infection of the wound, slow healing speed, and difficult vascularization.

Method used

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  • Self-healing injectable hydrogel dressing for restoring diabetic wound as well as preparation method and application thereof
  • Self-healing injectable hydrogel dressing for restoring diabetic wound as well as preparation method and application thereof
  • Self-healing injectable hydrogel dressing for restoring diabetic wound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 Preparation of hydrogel dressing

[0030](1) Preparation of alkylated pullulan (APu): Add 2 mmol of pullulan into 100 mL of deionized water, stir to dissolve completely; add 10 mmol of sodium periodate at a molar ratio of 1:5, The reaction was stirred and protected from light at room temperature for 5 hours. Then add ethylene glycol (molar ratio to sodium periodate: 2:1) to stop the reaction. After stirring for 1 hour, the reaction product was purified by 10,000 molecular weight dialysis bag for 3 days, and freeze-dried to obtain aldehydlated pullulan (APu);

[0031] (2) Preparation of F127-PEI polymer: Dissolve 0.5mmol F127 in 3.5mL dichloromethane, add 5mmol pyridine and 5mmol p-toluenesulfonyl chloride, react at room temperature for 24 hours, wash the reaction mixture with hydrochloric acid and saturated sodium bicarbonate, Precipitate with glacial ether, and the precipitated product is vacuum-dried to obtain F127-TsCl. Dissolve 0.25mmol F127-TsCl in 5...

Embodiment 2

[0034] Example 2 Preparation of Hydrogel Dressing

[0035] (1) Preparation of alkylated pullulan (APu): Add 2 mmol of pullulan into 100 mL of deionized water, stir to dissolve completely; add 10 mmol of sodium periodate at a molar ratio of 1:5, The reaction was stirred and protected from light at room temperature for 5 hours. Then add ethylene glycol (molar ratio to sodium periodate: 2:1) to stop the reaction. After stirring for 1 hour, the reaction product was purified by 10,000 molecular weight dialysis bag for 3 days, and freeze-dried to obtain aldehydlated pullulan (APu);

[0036] (2) Preparation of F127-PEI polymer: Dissolve 0.5mmol F127 in 3.5mL dichloromethane, add 5mmol pyridine and 5mmol p-toluenesulfonyl chloride, react at room temperature for 24 hours, wash the reaction mixture with hydrochloric acid and saturated sodium bicarbonate, Precipitate with glacial ether, and the precipitated product is vacuum-dried to obtain F127-TsCl. Dissolve 0.25mmol F127-TsCl in 50m...

Embodiment 3

[0039] Example 3 Preparation of Hydrogel Dressing

[0040] (1) Preparation of alkylated pullulan (APu): Add 2 mmol of pullulan into 100 mL of deionized water, stir to dissolve completely; add 10 mmol of sodium periodate at a molar ratio of 1:5, The reaction was stirred and protected from light at room temperature for 5 hours. Then add ethylene glycol (molar ratio to sodium periodate: 2:1) to stop the reaction. After stirring for 1 hour, the reaction product was purified by 10,000 molecular weight dialysis bag for 3 days, and freeze-dried to obtain aldehydlated pullulan (APu);

[0041] (2) Preparation of F127-PEI polymer: Dissolve 0.5mmol F127 in 3.5mL dichloromethane, add 5mmol pyridine and 5mmol p-toluenesulfonyl chloride, react at room temperature for 24 hours, wash the reaction mixture with hydrochloric acid and saturated sodium bicarbonate, Precipitate with glacial ether, and the precipitated product is vacuum-dried to obtain F127-TsCl. Dissolve 0.25mmol F127-TsCl in 50m...

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Abstract

The invention relates to a self-healing injectable hydrogel dressing for restoring a diabetic wound as well as a preparation method and application thereof. The preparation method is simple, free fromresidue of organic solvent, mild in reaction conditions, simple in operation and low in raw material cost at the same time. Meanwhile, the experiment result shows that the self-healing injectable hydrogel dressing for restoring the diabetic wound has excellent temperature sensitivity, self-healing performance and injectable performance, and can significantly accelerate the healing of the diabeticwound.

Description

technical field [0001] The invention relates to the technical field of biomedical materials and regenerative medicine, in particular to a self-healing injectable hydrogel dressing for diabetic wound repair and its preparation method and application. Background technique [0002] Diabetic chronic wound is one of the common clinical diseases and the main cause of disability caused by diabetes. Due to metabolic disorders, impaired immune function and sluggish nerve response of diabetic patients, diabetic wounds are often difficult to heal on their own, and the course of the disease is long. , the occurrence and treatment of diabetic wounds is an increasingly serious social problem. For diabetic wounds, in addition to the general etiological treatment according to the patient’s condition, in view of the common surgical contraindications in diabetic patients, thorough and effective debridement of wounds, local topical drugs and dressings, etc. are very important treatment method...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0057A61L26/0066A61L26/008A61L26/009A61L2300/30A61L2300/412A61L2300/604A61L2400/06C08L5/00C08L79/02C08L71/02
Inventor 毛葱雷波王敏徐天臻
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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