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A kind of flexible enzyme-free glucose sensing electrode and preparation method thereof

A technology for sensing electrodes and glucose, applied in the direction of material electrochemical variables, material analysis through electromagnetic means, instruments, etc., can solve problems such as the inability to apply micro sensors, and achieve improved catalytic performance, high adjustability, and high electrochemical performance. Active area effect

Active Publication Date: 2022-07-12
广州钰芯传感科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] This electrode solves the problem that the three-electrode system cannot be applied to microsensors, and the prepared interdigitated electrode can significantly eliminate concentration polarization during electrochemical testing due to the short distance between the working electrode and the counter electrode

Method used

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  • A kind of flexible enzyme-free glucose sensing electrode and preparation method thereof
  • A kind of flexible enzyme-free glucose sensing electrode and preparation method thereof
  • A kind of flexible enzyme-free glucose sensing electrode and preparation method thereof

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preparation example Construction

[0059] A preparation method of a flexible enzyme-free glucose sensing electrode modified by a rare earth-doped cobalt-phosphorus ternary alloy modified nanoporous copper, specifically comprising the following steps:

[0060] (1) Platinum plating on the counter electrode of the standard integrated three-electrode;

[0061] (2) modifying silver-silver chloride on the reference electrode of the standard integrated three-electrode;

[0062] (3) electrodepositing a copper layer on the working electrode of the standard integrated three-electrode;

[0063] (4) electrodepositing a gold-tin alloy on the front of the working electrode, and then removing the metal tin to obtain an electrode modified with nanoporous copper;

[0064] (5) Electrodepositing a rare earth-doped cobalt-phosphorus ternary alloy compound or a cobalt-phosphorus compound on the front of the working electrode to obtain a Co-M-P / NPC modified flexible enzyme-free glucose sensing electrode.

[0065] Further, in step ...

Embodiment 1

[0074] M=blank, preparation of Co-M-P / NPC composite electrode:

[0075] (1) The counter electrode of the standard integrated three-electrode is connected separately, and the standard platinum electrode is used as the counter electrode, and it is electrodeposited at a potential of -0.4V for 15 minutes, and the platinum plating solution is composed of H 2 PtCl 6 1mM and KCl 0.1M.

[0076] (2) The reference electrode of the standard integrated three-electrode is connected separately, and the silver wire electrode is used as the counter electrode, so that the current density is 0.3A / dm at 25°C 2 Electrodeposition for 20min in the same environment, the composition of silver-plated-silver chloride solution is: silver nitrate 40g / L, sodium thiosulfate 200g / L, potassium metabisulfite 40g / L, ammonium acetate 20g / L, thiosemicarbazide 0.6g / L.

[0077] (3) Washing, degreasing and washing the standard integrated three-electrode modified counter electrode and reference electrode, then c...

Embodiment 2

[0084] Preparation of M=La, Co-M-P / NPC composite electrode:

[0085] (1) The counter electrode of the standard integrated three-electrode is connected separately, and the standard platinum electrode is used as the counter electrode, and it is electrodeposited at a potential of -0.4V for 15 minutes, and the platinum plating solution is composed of H 2 PtCl 6 1mM and KCl 0.1M.

[0086] (2) The reference electrode of the standard integrated three-electrode is connected separately, and the silver wire electrode is used as the counter electrode, so that the current density is 0.3A / dm at 25°C 2 Electrodeposition for 20min in the same environment, the composition of silver-plated-silver chloride solution is: silver nitrate 40g / L, sodium thiosulfate 200g / L, potassium metabisulfite 40g / L, ammonium acetate 20g / L, thiosemicarbazide 0.6g / L.

[0087] (3) Washing, degreasing and washing the standard integrated three-electrode modified counter electrode and reference electrode, then conn...

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Abstract

The invention provides a rare-earth-doped cobalt-phosphorus ternary alloy modified nanoporous copper flexible enzyme-free glucose sensing electrode, and a Co-M-P / NPC composite structure is modified on the electrode surface, wherein M can be a non-radioactive rare earth element One or blank, it has a very high electrochemical active area and low charge transfer resistance, and greatly improves the electrocatalytic activity of the electrode through the porous structure and active materials. The Co-M-P / NPC composite electrode provided by the invention has high sensitivity, extremely low detection limit, low detection limit, good stability and anti-interference performance, and the detection range is 0.5-10.0mM. Its sensitivity is 1920 μA / mM cm in the range 2 , the detection limit is 182nM, and the response time is less than 4s, which can be applied to the actual detection of human blood sugar.

Description

technical field [0001] The invention belongs to the field of sensors for glucose detection, and relates to a preparation method of a flexible sensing electrode for detecting glucose without enzymes, in particular to the application of the sensing electrode in the rapid detection of glucose. Background technique [0002] Glucose circulates in the human body as blood sugar. Appropriate blood sugar levels help improve memory and cognitive performance. Too low blood sugar levels can lead to symptoms such as hypoglycemia or insulin shock. Too high blood sugar levels can lead to obesity or diabetes. Diabetes is one of the most common diseases in the world, and the incidence of diabetes has been increasing in recent decades, and it has been listed as one of the four major non-communicable diseases. Diabetes is a chronic disease that can cause various complications such as vision loss, renal failure, retinopathy, and stroke. Effective detection and treatment of diabetes has attract...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/327
CPCG01N27/30G01N27/3278
Inventor 奚亚男胡淑锦
Owner 广州钰芯传感科技有限公司
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