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Enhanced sampling using applied energy

A technology of energy and sampling area, applied in blood sampling devices, applications, diagnostic recording/measurement, etc., can solve problems such as complex wearable/pluggable devices

Inactive Publication Date: 2019-12-06
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But as wearable / insertable devices become more complex, with increased capabilities to perform in vivo assays (e.g., biological analyte presence and / or detection), there exists control over more individuals toward and through subsets or even individual microbes. Needle for fluid flow

Method used

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  • Enhanced sampling using applied energy
  • Enhanced sampling using applied energy
  • Enhanced sampling using applied energy

Examples

Experimental program
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Embodiment Construction

[0017] Various biomarkers / analytes (or "bioanalytes" in general) may have a relationship with a particular disease or condition. Monitoring of these biomarkers can provide valuable information about disease state (eg, presence / absence) or disease severity and progression. Non-limiting examples of the relationship between different biomarkers / analytes and diseases or conditions are provided in Table 1, which includes overall function (e.g. skin barrier) and provides examples of analytes that can be tested and the conditions or conditions to which they may be associated. disease. In addition to those listed in Table 1, other non-limiting conditions and associated analytes include: dehydration and electrolytes; obesity and ketones, triglycerides and insulin; asthma and blood parameters; wound management and on-skin or wound Wound moisture, pH and bacterial composition at the site; diabetes and glucose, insulin and ketones; stress and cortisol; malnutrition and vitamins and elect...

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PUM

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Abstract

The present disclosure is directed to enhanced sampling of bioanalytes from bodily fluids using wearable and / or insertable devices. In some embodiments, an apparatus (100, 500, 600) for sampling bioanalyte(s) in tissue (107, 507, 607) may include: a base (102, 502, 602) having conduit(s) adapted to receive fluid extracted from the tissue; microneedles (106, 306, 506, 606) fluidly coupled with theconduit(s) and adapted to be pierced into the tissue; a plurality of individually-controllable energy emitters (112, 114, 350, 612, 614); and logic (90) operably coupled with the plurality of individually-controllable energy-emitters. The logic may be adapted to operate a subset of the plurality of individually-controllable energy emitters to apply energy at a first subset of the microneedles to induce bioanalyte flow through tissue towards the first subset or a second subset of the microneedles, or through the first subset or a second subset of the microneedles.

Description

technical field [0001] This disclosure relates generally to healthcare. More specifically, but not exclusively, various techniques disclosed herein relate to improved sampling of various biological analytes from bodily fluids using insertable and / or wearable devices. Background technique [0002] Biomarkers and / or analytes sampled from biopsy (often collectively referred to herein as "bioanalytes") can provide a variety of information about the molecular composition of blood, plasma, interstitial fluid, sweat, lymph, and other bodily fluids, Information that is substantial for clinical diagnosis is thereby provided. Collection of biological analytes from living tissue - including from fluids such as interstitial fluid, blood and lymph - is typically performed in clinical settings using benchtop microfluidic devices. [0003] As research progresses on device miniaturization and reduced power consumption, and as manufacturing processes improve, wearable / insertable devices ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/15A61B5/157A61B5/145A61B10/00A61B5/155
CPCA61B5/14503A61B5/14507A61B5/150022A61B5/150091A61B5/150389A61B5/150862A61B5/15087A61B5/150877A61B5/150969A61B5/150984A61B5/155A61B5/157A61B10/0045A61B2010/008
Inventor L·C·格哈特M·T·约翰逊N·E·乌尊巴加卡瓦P·M·R·沃泰尔布尔T·R·格罗布H·R·施塔伯特
Owner KONINKLJIJKE PHILIPS NV