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Pharmaceutical composition for treating suppurative arthritis

A technology for treating septic arthritis and drugs, applied in the field of medicine, can solve the problems of limited efficacy, limitation, large side effects, etc.

Active Publication Date: 2019-12-13
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these therapies are either limited by limited efficacy and relatively large side effects, or cause relatively large trauma to the patient, so they are not yet satisfactory.

Method used

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  • Pharmaceutical composition for treating suppurative arthritis
  • Pharmaceutical composition for treating suppurative arthritis
  • Pharmaceutical composition for treating suppurative arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Each component of the pharmaceutical composition described in the present embodiment and consumption thereof are shown in the following table:

[0025]

[0026]

[0027] The preparation method is as follows: 1) uniformly mixing phellodendron and carnosic acid; 2) dissolving sodium benzoate in a mixed medium composed of glycerin accounting for 25% of the total mass of glycerin and water accounting for 20% of the total mass of water , and then add the mixture obtained in step 1) under stirring at 40°C and fully dissolve it; 3) Carbomer 941, sodium alginate, polyvinylpyrrolidone, sodium carboxymethylcellulose, Sodium acetate, eucalyptus oil, Tween 80, the remaining amount of glycerin and the remaining amount of water are stirred at 45°C until a uniform gel matrix is ​​obtained; 4) Add the mixture obtained in step 2) to step 3 while hot ) in the obtained gel matrix, stir and mix and cool to obtain a gel.

Embodiment 2

[0029] Each component of the pharmaceutical composition described in the present embodiment and consumption thereof are shown in the following table:

[0030] components Dosage Phellodendron 7g Carnosic acid 0.6g Carbomer 941 30g sodium alginate 20g Polyvinylpyrrolidone 15g Sodium carboxymethyl cellulose 15g Sodium edetate 1.5g sodium benzoate 1g Eucalyptus oil 0.5g Tween 80 2g glycerin 150g water Add to 1000g

[0031] The preparation method is as follows: 1) uniformly mixing phellodendron and carnosic acid; 2) dissolving sodium benzoate in a mixed medium composed of glycerin accounting for 25% of the total mass of glycerin and water accounting for 20% of the total mass of water , and then add the mixture obtained in step 1) under stirring at 40°C and fully dissolve it; 3) Carbomer 941, sodium alginate, polyvinylpyrrolidone, sodium carboxymethylcellulose, Sodium acetate, eucalyptus oil, Twe...

Embodiment 3

[0033] Each component of the pharmaceutical composition described in the present embodiment and consumption thereof are shown in the following table:

[0034] components Dosage Phellodendron 8g Carnosic acid 0.7g Carbomer 941 35g sodium alginate 25g Polyvinylpyrrolidone 20g Sodium carboxymethyl cellulose 20g Sodium edetate 1.5g sodium benzoate 1g Eucalyptus oil 0.5g Tween 80 2g glycerin 150g water Add to 1000g

[0035] The preparation method is as follows: 1) uniformly mixing phellodendron and carnosic acid; 2) dissolving sodium benzoate in a mixed medium composed of glycerin accounting for 25% of the total mass of glycerin and water accounting for 20% of the total mass of water , and then add the mixture obtained in step 1) under stirring at 40°C and fully dissolve it; 3) Carbomer 941, sodium alginate, polyvinylpyrrolidone, sodium carboxymethylcellulose, Sodium acetate, eucalyptus oil, Twe...

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Abstract

The invention discloses a pharmaceutical composition for treating suppurative arthritis. The pharmaceutical composition is characterized by comprising the following components: 1) obakunone; 2) carnosic acid; and 3) a pharmaceutically acceptable carrier, wherein the mass ratio of obakunone to carnosic acid is (5-9): (0.4-0.8). The pharmaceutical composition has excellent treatment and improvementeffects on suppurative arthritis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating suppurative arthritis. Background technique [0002] Septic arthritis, also known as bacterial arthritis or septic arthritis, is a type of arthritis that causes damage to joint structure and loss of function. Septic arthritis tends to occur in frail patients such as children and the elderly and patients with chronic joint diseases, and the majority of patients are male. After being ill, the main symptoms are local redness, swelling, heat, pain, limited movement of the joints, and systemic symptoms such as high fever. [0003] In terms of etiology, most septic arthritis is caused by septic pathogens. These pathogenic bacteria can enter the joint site to multiply infection through blood, surgery, joint cavity puncture, damage to the joint and its adjacent tissues, or spread to the joint from the adjacent infection focus. [0004] Regard...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61K31/192A61K9/06A61K47/32A61K47/36A61K47/38A61P19/02
CPCA61K9/0014A61K9/06A61K31/192A61K31/585A61K47/32A61K47/36A61K47/38A61P19/02A61K2300/00
Inventor 王天枢王增冕于涛魏巍唐华羽
Owner JIAMUSI UNIVERSITY