Nano-micelle with in-situ hydrogen production function and preparation method and application thereof

Abstract

The invention discloses a nano-micelle with an in-situ hydrogen production function and a preparation method and application thereof. The nano-micelle is prepared from fluorinated chitosan, [FeFe] hydrogenase and a chemotherapeutic drug. The [FeFe] hydrogenase and the chemotherapeutic drug are entrapped in an inner core of the nano-micelle, and the fluorinated chitosan forms a shell of the nano-micelle. The nano-micelle disclosed by the invention can effectively penetrate a bladder mucous membrane layer to reach a bladder cancer lesion area, and the nano-micelle stably generates hydrogen molecules under the stimulation of near-infrared laser. The nano-micelle can be applied to photo-hydrogen treatment of tumor cells, and the generated hydrogen is combined with a loaded drug to effectivelykill the tumor cells and to inhibit tumor growth.

Description

technical field [0001] The invention relates to the field of nanomedical materials, in particular to a nanomicelle with in-situ hydrogen production and its preparation method and application. Background technique [0002] Bladder cancer is a common malignancy of the genitourinary system and is the ninth most common tumor in the world. In my country, both the morbidity and mortality of bladder cancer rank first in tumors of the urinary system, and its incidence has been increasing year by year and younger in recent years. Clinically, more than 75% of bladder cancers are non-muscle-invasive bladder cancer (NMIBC), and 30% to 80% of patients will relapse within 5 years after transurethral resection of bladder tumors, and 10% to 20% of non-invasive bladder cancers Patients with bladder cancer can progress to muscle-invasive bladder cancer with strong metastatic potential. [0003] Intravesical chemotherapy is a kind of intracavitary chemotherapy. Doctors use a catheter to inj...

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Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a nano-micelle with in-situ hydrogen production and its preparation method and application, aiming at solving the problem that the existing hydrogen molecules are extremely volatile and difficult to store stably, which limits its Application issues in tumor therapy

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