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Application of SDPR autoantibody detection reagent in preparing lung cancer screening kit

A technology of autoantibodies and kits, applied in biological testing, measuring devices, material inspection products, etc., can solve the problems of no lung cancer existing technology, no SDPR protein, etc., and achieve effective screening and good application prospects

Pending Publication Date: 2019-12-31
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no relevant reports on SDPR protein autoantibodies, and there is no prior art related to lung cancer

Method used

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  • Application of SDPR autoantibody detection reagent in preparing lung cancer screening kit
  • Application of SDPR autoantibody detection reagent in preparing lung cancer screening kit
  • Application of SDPR autoantibody detection reagent in preparing lung cancer screening kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Relationship between SDPR autoantibodies in plasma and lung cancer

[0027] 1. Clinical data

[0028] 59 cases of lung cancer patients and 29 cases of healthy controls were selected. The basic information is as follows:

[0029] Basic Information lung cancer patients healthy control number of people 59 29 age 54.5±7.6 42±8.9 male ratio 37(62.7％) 13(46.7％)

[0030] 2. Detection principle

[0031] HuProt TM The SDPR protein is immobilized on the human protein custom chip (the SDPR protein used is a full-length protein, and the protein sequence number is ENSP00000305675). After incubation with serum, SDPR autoantibodies (mainly including IgG and IgM antibodies, and some other types Antibodies) will bind to it, wash to remove unbound antibodies and other proteins, and then detect with anti-human IgM fluorescently labeled secondary antibody (cy5-labeled, red) and anti-human IgG fluorescent secondary antibody (cy3-labeled, g...

Embodiment 2

[0048] Embodiment 2 The composition of detection kit of the present invention and its application method

[0049] 1. Kit composition

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Abstract

The present invention relates to the field of in vitro diagnostic reagents, and in particular to the application of an SDPR autoantibody detection reagent in preparing a lung cancer screening kit. Inthe present invention, that the autoantibody level of the SDPR protein in the serum of lung cancer patients is significantly higher than that of healthy patients is discovered for the first time. According to the technical scheme of the present invention, the SDPR protein autoantibody detection reagent is used to prepare a lung cancer screening kit, and effective lung cancer screening can be realized.

Description

technical field [0001] The invention relates to the field of in vitro diagnostic reagents, in particular to the use of SDPR autoantibody detection reagents in the preparation of lung cancer screening kits. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world. Its morbidity and mortality are increasing year by year. Currently, the incidence rate ranks first in the world, which seriously threatens human health and life. [0003] Lung cancer is a disease that is good at concealment. It often shows clinical symptoms when the disease develops to an advanced stage. 70-80% of lung cancer patients are already in the middle or late stage when they are diagnosed with lung cancer symptoms. The best cure time, five-year survival rate is low. For patients with early lung cancer, timely treatment can greatly improve the 5-year survival rate and quality of life of the patients. Therefore, early diagnosis and effective screening of lung cancer ...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/68G01N33/535
CPCG01N33/57423G01N33/57488G01N33/6854G01N33/6884G01N33/535G01N2333/4746
Inventor 刘丹史静宇张立李为民
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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