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Use of detection reagent of MSI1 autoantibody in preparation of lung cancer screening kit

An autoantibody, MSI1 technology, applied in biological tests, measuring devices, material inspection products, etc., can solve the problems of no lung cancer existing technology, no MSI1 protein, etc., and achieve the effect of effective screening and good application prospects.

Pending Publication Date: 2019-12-31
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no related reports on MSI1 protein autoantibodies, and there is no prior art related to lung cancer.

Method used

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  • Use of detection reagent of MSI1 autoantibody in preparation of lung cancer screening kit
  • Use of detection reagent of MSI1 autoantibody in preparation of lung cancer screening kit
  • Use of detection reagent of MSI1 autoantibody in preparation of lung cancer screening kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Relationship between MSI1 autoantibodies in plasma and lung cancer

[0027] 1. Clinical data

[0028] 59 cases of lung cancer patients and 29 cases of healthy controls were selected. The basic information is as follows:

[0029] Basic Information lung cancer patients healthy control number of people 59 29 age 54.5±7.6 42±8.9 male ratio 37(62.7％) 13(44.8％)

[0030] 2. Detection principle

[0031] HuProt TM MSI1 protein is immobilized on the human protein custom chip (the MSI1 protein used is a full-length protein, and the protein sequence number is Ensembl: ENSP00000446710). After incubation with serum, MSI1 autoantibodies (mainly including IgG and IgM antibodies, and some Other types of antibodies) will bind to it, wash to remove unbound antibodies and other proteins, and then detect with anti-human IgM fluorescently labeled secondary antibody (cy5-labeled, red) and anti-human IgG fluorescent secondary antibody (cy3-la...

Embodiment 2

[0048] Embodiment 2 The composition of detection kit of the present invention and its using method

[0049] 1. Kit composition

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PUM

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Abstract

The invention relates to the field of in vitro diagnostic reagents, and in particular to use of a detection reagent of a MSI1 autoantibody in preparation of a lung cancer screening kit. The inventionfinds that the level of autoantibody of MSI1 protein in the serum of lung cancer patients is significantly lower than that in healthy patients for the first time, and can realize effective screening of lung cancer by using the reagent of detecting the autoantibody of MSI1 protein for the preparation of a lung cancer screening kit.

Description

technical field [0001] The invention relates to the field of in vitro diagnostic reagents, in particular to the use of MSI1 autoantibody detection reagents in the preparation of lung cancer screening kits. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world. Its morbidity and mortality are increasing year by year. Currently, the incidence rate ranks first in the world, which seriously threatens human health and life. [0003] Lung cancer is a disease that is good at concealment. It often shows clinical symptoms when the disease develops to an advanced stage. 70-80% of lung cancer patients are already in the middle or late stage when they are diagnosed with lung cancer symptoms. The best cure time, five-year survival rate is low. For patients with early lung cancer, timely treatment can greatly improve the 5-year survival rate and quality of life of the patients. Therefore, early diagnosis and effective screening of lung cancer ...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/68G01N33/535
CPCG01N33/57423G01N33/57488G01N33/6854G01N33/6884G01N33/535G01N2333/4746
Inventor 刘丹史静宇罗永霄尹逸楠孙鹏
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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