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Preparation method of coated guanidinoacetic acid

A guanidinoacetic acid and coating technology, which is applied in the field of preparation of coated guanidinoacetic acid, can solve the problems of low bioavailability, inability to achieve sustained release, and high degradation rate, so as to reduce degradation rate, improve rumen passing rate, and stabilize good sex effect

Pending Publication Date: 2020-01-10
固安君德同创生物工程有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the guanidinoacetic acid obtained by the current preparation method is in the form of powder crystals, which has poor fluidity in actual use, especially in the use of ruminants, the product has a high degradation rate in the rumen, and cannot achieve sustained release after passing through the rumen effect, low bioavailability

Method used

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  • Preparation method of coated guanidinoacetic acid
  • Preparation method of coated guanidinoacetic acid
  • Preparation method of coated guanidinoacetic acid

Examples

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Effect test

Embodiment 1-6

[0036] Embodiment 1-6 A kind of coated guanidinoacetic acid

[0037] Examples 1-6 are respectively a kind of coated guanidinoacetic acid, and its raw material formula is shown in Table 1.

[0038] The raw material formula of table 1 embodiment 1-6

[0039]

Embodiment 7

[0040] Example 7 A preparation method of coated guanidinoacetic acid

[0041] This embodiment is used to prepare the guanidinoacetic acid described in any one of embodiments 1-6, comprising the following steps carried out in sequence:

[0042] (1) Pretreatment

[0043] The powder guanidinoacetic acid is first ultrafinely pulverized, then shaken through an 80-mesh sieve, graded and sieved, and the 80-mesh guanidinoacetic acid is taken as a raw material;

[0044] (2) Ball core preparation

[0045] After pulverizing and sieving, 400 parts of powder guanidinoacetic acid and 4 parts of gelatinized starch solutions with a concentration of 40% and 16 parts of hydroxypropyl methylcellulose solutions with a concentration of 10% were placed in a mixer and mixed evenly. After being extruded into granules by a swinging granulator, they are added to a rounding machine to form spherical granules. The spherical granules are swayed through a 40-mesh screen, sorted, graded and sieved, and th...

Embodiment 8-11

[0054] Example 8-11 A preparation method of coated guanidinoacetic acid

[0055] Embodiments 8-11 are respectively a preparation method for coating guanidinoacetic acid, which is used to prepare the guanidinoacetic acid described in any one of Examples 1-6, and the preparation steps are the same as those in Example 7, with the difference The difference is that the technical parameters in the preparation process of the coated guanidinoacetic acid are different, see Table 2 below for details.

[0056] Table 2 Technical parameters in the preparation process of Examples 8-11

[0057]

[0058] In this example, the active ingredient of the second-coated guanidinoacetic acid finally obtained in Example 7 can be as high as 67.8%. The active ingredient of the second coating of the finally obtained guanidinoacetic acid in Example 8 can be as high as 78.7%. The active ingredient of the guanidinoacetic acid finally obtained in Example 9 after secondary coating can be as high as 86.8%...

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Abstract

The invention relates to a preparation method of coated guanidinoacetic acid. Guanidinoacetic acid and a coating material are taken as raw materials, and the coating material is sprayed on the surfaces of granular guanidinoacetic acid through a bottom spraying system of a coating machine. The preparation method comprises the following steps: (1) pretreatment; (2) pellet core preparation; (3) primary coating; and (4) secondary coating. The invention optimizes a guanidinoacetic acid coating process including selection of auxiliary materials and selection of all parameters in the preparation process. The coated guanidinoacetic acid which is good in stability and high in bioavailability can be prepared through the method. Especially for ruminants, the degradation rate of the product existing in the rumen is reduced, the slow release effect is achieved after the product passes through the rumen, and the bioavailability is high. The method is applicable to the field of feed additive preparation.

Description

technical field [0001] The invention belongs to the field of feed additive preparation, and in particular relates to a preparation method of coated guanidinoacetic acid. Background technique [0002] Guanidinoacetic acid belongs to amino acids and their derivatives. It is a functional feed additive, suitable for livestock and poultry that mainly use plant-based diets. The use of guanidinoacetic acid plays an important role in improving the production performance of livestock and poultry, improving meat quality, promoting energy metabolism and increasing the value of protein feed resources. Most of the guanidinoacetic acid obtained by the current preparation method is in the form of powder crystals, which has poor fluidity in actual use, especially in the use of ruminants, the product has a high degradation rate in the rumen, and cannot achieve sustained release after passing through the rumen effect, low bioavailability. Contents of the invention [0003] The purpose of ...

Claims

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Application Information

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IPC IPC(8): A23K20/105A23K20/163A23K20/158A23K40/10A23K40/30A23K50/10
CPCA23K20/105A23K20/163A23K20/158A23K40/10A23K40/30A23K50/10
Inventor 杨立彬沈承琪刘伟国
Owner 固安君德同创生物工程有限公司
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