Pharmaceutical composition with spermatogenic effect

A composition and drug technology, applied in the field of pharmaceutical preparations, can solve problems such as unfavorable production and marketing, high cost, and long production cycle

Active Publication Date: 2020-01-10
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the medicine described in this patent application can achieve the purpose of nourishing yin and tonifying kidney, producing sperm, and enhancing human kidney function, the main drug of the medicine is expensive Cordyceps sinensis, the cost is high, and the extraction and preparation process is cumbersome and the production cycle is long. Not conducive to production and marketing

Method used

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  • Pharmaceutical composition with spermatogenic effect
  • Pharmaceutical composition with spermatogenic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Prescription: Dried oyster meat 4600g, Morinda officinalis 2900g, Cistanche 1800g, sea cucumber 700g.

[0019] 2. Preparation method

[0020] (1) Take the raw material drug, dry and pulverize it, add 25 times of 80°C hot water for ultrasonic extraction for 20 minutes, collect the extract and concentrate it into an extract;

[0021] (2) Add 4 volume times of ethanol precipitation to the obtained extract, collect the precipitate, centrifuge and freeze-dry to obtain a freeze-dried powder;

[0022] (3) Dissolve the obtained lyophilized powder in water, and dialyze through a dialysis bag with a molecular weight cut-off of 3500 Daltons, collect the polysaccharide dialysate with a molecular weight greater than 3500 Daltons, concentrate and freeze-dry to obtain the polysaccharide extract ;

[0023] (4) Add appropriate amount of dextrin and starch to 1.2 kg in the obtained polysaccharide extract, add 75% alcohol to make granules, then dry, sieve, and granulate, and use pack...

Embodiment 2

[0026] 1. Prescription: Dried oyster meat 5238g, Morinda officinalis 2387g, Cistanche 1654g, sea cucumber 721g.

[0027] 2. Preparation method

[0028] (1) Take the raw material drug, dry and pulverize it, add 20 times 80°C hot water for ultrasonic extraction for 30 minutes, collect the extract and concentrate it into an extract;

[0029] (2) Add 4 volume times of ethanol precipitation to the obtained extract, collect the precipitate, centrifuge and freeze-dry to obtain a freeze-dried powder;

[0030] (3) Dissolve the obtained lyophilized powder in water, and dialyze through a dialysis bag with a molecular weight cut-off of 3500 Daltons, collect the polysaccharide dialysate with a molecular weight greater than 3500 Daltons, concentrate and freeze-dry to obtain the polysaccharide extract ;

[0031] (4) Add appropriate amount of dextrin and starch to 1.2 kg in the obtained polysaccharide extract, add 75% alcohol to make granules, then dry, sieve, and granulate, and use packagi...

Embodiment 3

[0034] 1. Prescription: Dried oyster meat 3962g, Morinda officinalis 3413g, Cistanche 1946g, sea cucumber 679g.

[0035] 2. Preparation method

[0036] (1) Take the raw material drug, dry and pulverize it, add 15 times of hot water at 75°C for ultrasonic extraction for 30 minutes, collect the extract and concentrate it into an extract;

[0037] (2) Add 4 volume times of ethanol precipitation to the obtained extract, collect the precipitate, centrifuge and freeze-dry to obtain a freeze-dried powder;

[0038] (3) Dissolve the obtained lyophilized powder in water, and dialyze through a dialysis bag with a molecular weight cut-off of 3500 Daltons, collect the polysaccharide dialysate with a molecular weight greater than 3500 Daltons, concentrate and freeze-dry to obtain the polysaccharide extract ;

[0039] (4) Add appropriate amount of dextrin and starch to 1.2 kg in the obtained polysaccharide extract, add 75% alcohol to make granules, then dry, sieve, and granulate, and use p...

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Abstract

The invention relates to a pharmaceutical composition with a spermatogenic effect. The pharmaceutical composition is composed of effective components and medically acceptable auxiliary materials, andis characterized in that the effective components are a polysaccharide extract with a molecular weight of 3500 Daltons, wherein the polysaccharide extract is prepared from the following raw material medicines in percentage by weight: 37-55% of dried oyster meat, 23-35% of morinda roots, 14-22% of desertliving cistanche and 6-8% of apostichopus japonicus. The pharmaceutical composition disclosed bythe invention has the advantages of simple medicines, special effect and remarkable effect.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a pharmaceutical preparation containing an undetermined structure from a raw material of traditional Chinese medicine, and the pharmaceutical preparation has spermatogenic effect. Background technique [0002] Infertility is a common clinical problem, affecting nearly 15% of couples worldwide. About 50% of infertility factors are caused by male factors, including oxidative stress damage, diabetes-induced hyperglycemia damage, DNA damage, chronic intermittent heat stress and copper exposure. Currently, oxidative stress damage has been identified as an important factor leading to reproductive dysfunction leading to male infertility. Oxidative stress can lead to atrophy and reduction of spermatogenic cells at all levels in the male testis, as well as a decrease in the number of mature sperm, and most of the mature sperm are abnormal. [0003] At present, the main clinical drug for male oxi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/746A61P15/08A61K35/618
CPCA61K35/618A61K36/185A61K36/64A61K36/746A61K2236/331A61K2236/39A61K2236/53A61P15/08A61K2300/00
Inventor 李世杰刘涛宋卓悦叶贤英陈瑶
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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