Magnetoencephalogram multi-modal image registration system and method based on MRI and OPM

Abstract

The invention discloses a magnetoencephalogram multi-modal image registration system based on MRI and OPM. The system comprises a double-mark combined type registration module, the registration modulecomprises an OPM brain magnetic imaging marking module and a nuclear magnetic resonance imaging marking module. The OPM brain magnetic imaging marking module comprises a flexible circuit board and acircular positioning coil arranged on the flexible circuit board. The nuclear magnetic resonance imaging marking module comprises a reference block which is made of a non-magnetic material and is internally provided with solid oil; the flexible circuit board is detachably arranged on the surface of the reference block; a positioning part of the flexible circuit board is arranged on the upper surface of the reference block; the reference point information of the position where the circular positioning coil is located in the magnetoencephalogram and the space coordinate system information of thereference point of the position where the solid oil of the MRI image is located are obtained; image registration can be carried out by adopting a basic and simple reference point positioning method,so that the registration precision is improved, the calculation time is greatly shortened, and the advancing pace of a new generation of magnetoencephalogram technology from an experimental design simulation stage to a medical clinical application stage is promoted.

Description

technical field [0001] The invention relates to the field of magnetoencephalography technology, in particular to an MRI and OPM-based multimodal image registration system and method for magnetoencephalography. Background technique [0002] At present, the existing magnetic brain devices based on the principle of Superconducting Quantum Interference Device (SQUID) are bulky and heavy, and require regular replacement of liquid helium. Therefore, the MEG detection of children and patients with epilepsy is greatly limited. Compared with other types of magnetometers, the Optically Pumped Magnetometer (OPM for short) has incomparable advantages in terms of performance indicators. It has surpassed SQUID at present, making the sensitivity level of human magnetic field measurement from fT level into Sub-fT class. Compared with SQUID, OPM does not require a cryogenic maintenance system and can be integrated on a chip. Due to its small size and low cost, it has been used in biomagnet...

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Problems solved by technology

[0003] The research trend of the imaging of magnetic brain activity is to carry out medical clinical applications, so that the subjects of magnetic brain imaging are required to perform MRI scans of the head, and then perform multimodal analysis on the real human head, and conduct MRI scans of the brain. The difficulty of multimodal analysis is that the positioning and registration of markers under different equipment are not accurate. At present, the commonly used positioning method is to manually mark marks on the head of the subject based on experience, and then place the corresponding markers of different equipment respectively. Placed at the marked mark before detection, this positioning method is extremely inaccurate, causing a large error in the registration of the magnetoencephalogram and the real head model, which cannot meet the registration requirements of the magnetoencephalogram and the real head model. high occasions, which limits its development

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