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Natural and organic binder compositions for oral solid dosage forms

A technology of composition and adhesive, which is applied in the direction of pill delivery, medical preparations of non-active ingredients, pharmaceutical formulations, etc., and can solve the problems of poor compressibility, reduced fluidity, and unfavorable processing characteristics of powder mixtures

Pending Publication Date: 2020-02-21
BIOGRUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, to the best of our knowledge, efforts to formulate all-natural or essentially all-natural nutritional supplements in solid form that contain only or nearly exclusively certified organic / natural ingredients have been unsuccessful to date
In particular, these developments have not resulted in tablets ensuring reliable properties such as acceptable tablet hardness, good friability and / or acceptable dissolution of the active ingredient
Conversely, the use of natural ingredients can lead to unfavorable processing characteristics such as reduced flowability, poor compressibility of powder mixtures, and batch-to-batch variability of finished products

Method used

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  • Natural and organic binder compositions for oral solid dosage forms
  • Natural and organic binder compositions for oral solid dosage forms
  • Natural and organic binder compositions for oral solid dosage forms

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] Accessories: grade: %w / w Guar Gum 21CFR184.1339 / organic 30 gum arabic FCC / organic 35 Amylopectin powder USP / NF / organic 30 apple fiber organic 5

[0037] Dry adhesive compositions were produced by mixing the ingredients in a V-shaped powder mixer until a homogeneous mixture was obtained. The dry powder mixture was also granulated in a planetary mixer by slowly adding sufficient water until granules formed. The granules were then sieved through a 1-2 mm sieve and dried in an oven at 30°C until the moisture content of the granules was below 5%. Sieve the dried granules again through the same sieve.

[0038] In the following examples, dry adhesive compositions were produced as in Example 1, but, as in Example 1, with different ingredients or different amounts of ingredients per weight:

example 2

[0040] Accessories: grade: %w / w Guar Gum 21CFR184.1339 / organic 25 gum arabic FCC / organic 35 Amylopectin powder USP / NF / organic 30 apple fiber organic 10

example 3

[0042] Accessories: grade: %w / w Guar Gum 21CFR184.1339 / organic 30 gum arabic FCC / organic 35 Amylopectin powder USP / NF / organic 30 Cellulose powder FCC 5

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PUM

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Abstract

The present invention relates to a binder composition of different natural / organic binders to ensure efficient tablet manufacturing and batch to batch consistency with avoiding the risk of having capping or lamination problems during the manufacturing process. The composition comprises a blend of components selected from a blend of components selected from : a. of about 5% to about 65% by weight guar gum, xanthan gum or a combination thereof; b. of about 5% to about 65% by weight gum arabic; of about 5% to about 65% by weight pullulan, honey powder, agave powder, or isolated pea protein or anycombination of the foregoing; and d. about 1% to about 15% by weight natural plant fibers, all weight percentages being based on the dry weight of the binder composition.

Description

technical field [0001] The present invention relates to the field of natural binding compositions for oral solid dosage forms. More specifically, the present invention relates to providing cohesiveness to ingredients of solid dosage forms by natural binder compositions in the form of premixes to form granules or tablets. This ensures the integrity of the processed solid dosage form and enables clean labeling of the finished product. Background technique [0002] The use of natural additives instead of artificial additives in the food and pharmaceutical industries has gradually increased over the past few years, and the diversity of their uses is also attracting interest as consumers become more aware of healthy and natural foods. In terms of consumer preferences, as it relates to pharmaceutical dosage forms and health functional foods, there is an increasing emphasis on well-being, health and eco-friendliness factors in the production process, and as a result, many products...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/46
CPCA61K47/36A61K47/46A61K9/205A61K9/2068
Inventor F·施佩希特M·尤尼斯
Owner BIOGRUND