Application of oxidized cyclodextrin in preparing disintegrants

A technology of cyclodextrin and disintegrant, which is applied in the field of medicine, can solve the problem of less research on cyclodextrin disintegrant, and achieve the effect of shortening the time

Active Publication Date: 2020-03-06
CHONGQING TECH & BUSINESS UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, sodium methyl starch, low-substituted propyl cellulose, cross-linked polyvinylpyrrolidone, microcrystalline cellulose, cross-linked methyl cellulose sodium , pregelatinized starch, etc. are used to prepare disintegrants, but there are few related studies on cyclodextrin-based disintegrants

Method used

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  • Application of oxidized cyclodextrin in preparing disintegrants
  • Application of oxidized cyclodextrin in preparing disintegrants
  • Application of oxidized cyclodextrin in preparing disintegrants

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Embodiment

[0020] Preparation of oxidized β-cyclodextrin with different oxidation degrees, the quality of β-cyclodextrin used, the volume of hydrogen peroxide and the quality of the final prepared oxidized cyclodextrin are shown in Table 1, and each group is marked as H1 and H2 respectively , H3, H4, H5, H6, H7, H8, H9, H10 were all prepared as follows:

[0021] Dissolve β-cyclodextrin in 20mL of distilled water, then add hydrogen peroxide, shake the reaction at room temperature in a shaking table with a rotation speed of 300r / min and a shaking amplitude of 25mm until the hydrogen peroxide is completely consumed, take out the reaction solution and use ice water as the The washing solution was filtered and washed 5 times to obtain a solid phase, which was dried at 110° C. for 3 hours to obtain an oxidized cyclodextrin.

[0022] Table 1

[0023] group β-cyclodextrin (g) Hydrogen peroxide (mL) Oxidized β-cyclodextrin (g) H1 5 0 4.3596 H2 5 0.2 4.4408 H3 5 ...

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Abstract

The invention relates to an application of oxidized cyclodextrin in preparing disintegrants, and belongs to the technical field of medicines. Through control of the oxidation degree of cyclodextrin, the disintegration time of oxidized cyclodextrin serving as a disintegrant reagent can be controlled. According to experiments, disintegration time is reduced along with increase of the oxidation degree of cyclodextrin, and when the disintegration time is reduced to a certain degree, the disintegration time is not reduced and tends to be stabile. Therefore, oxidized cyclodextrin which can meet requirements can also be selected as a disintegrant according to disintegration time required by a target medicine, so that time for searching a proper disintegrant is shortened.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of oxidized cyclodextrin in the preparation of disintegrants. Background technique [0002] In recent years, with the development of new technologies in the medical field, especially in the polymer industry, the emergence of a large number of new drugs will promote the development and application of pharmaceutical excipients, including a key excipient - high-efficiency disintegrants. The disintegrant is an important auxiliary material in the process of tablet production. It is used to overcome the physical force required by the pressure and the binder, and to accelerate the disintegration of the tablet into fine particles in the gastrointestinal fluid, so that the tablet meets the specified time requirements. The requirements of internal fragmentation can improve the dissolution rate and bioavailability of drugs. [0003] The molecular shape of β-cyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/40
CPCA61K47/40
Inventor 魏星跃王星敏
Owner CHONGQING TECH & BUSINESS UNIV
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