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Zinc:usnic acid complexes, oral care compositions and methods of use

A technology for oral care and complexes, which can be used in drug combinations, zinc organic compounds, oral care, etc., and can solve problems such as insufficient water solubility and efficacy attributes.

Inactive Publication Date: 2020-03-06
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Current antimicrobial products do not adequately address water solubility and efficacy attributes

Method used

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  • Zinc:usnic acid complexes, oral care compositions and methods of use
  • Zinc:usnic acid complexes, oral care compositions and methods of use
  • Zinc:usnic acid complexes, oral care compositions and methods of use

Examples

Experimental program
Comparison scheme
Effect test

example 4

[0123] Example 4 - Solubility Determination

[0124] Solubility determinations of zinc: lichenate complexes were performed using standard techniques. The solubility of lichenic acid in deionized water at about 35°C has been reported to be about 6.3 ppm (see Jin et al., Solubility of (+)-Usnic Acid in Water, Ethanol, Acetone, Ethyl Acetate and n-Hexane, J Solution Chem. , 2013, 42:1018-1027). The zinc: lichenate complex exhibits a solubility of about 13.5 ppm in deionized water at room temperature.

Embodiment 5

[0125] Example 5 - Antimicrobial Efficacy of Zinc: Lichenate Complex against Oral Bacteria

[0126]Bacteria (A. naesli, L. casei, Streptococcus oralis, Fusobacterium nucleatum and Veilonella parvula) collected from the chemostat were centrifuged at about 15,000 rpm to a volume of about 1 ml. Resuspend the pelleted bacteria in the appropriate zinc: lichenate complex treatment or in sterile medium and ethanol. The tubes were then inverted 3 times and incubated at about 37°C for about 1 hour. After incubation, approximately 1 mL of D / E neutralization broth was added to each sample. The samples were then centrifuged at about 15,000 rpm for about 10 minutes to pellet the bacteria. Remove the supernatant and resuspend the pellet in approximately 1 mL of 0.25x TSB. The samples were again centrifuged at about 15,000 rpm for about 10 minutes. Remove the supernatant and resuspend the pellet in approximately 1.5 mL of 0.25x TSB. In a 96-well plate, transfer approximately 100 μL of s...

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PUM

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Abstract

Zinc:usnic acid complexes having a 1:2 zinc to usnate molar ratio and methods of preparing them. Oral care compositions comprise the Zn:usnate complexes may be useful to improve oral health.

Description

technical field [0001] Examples or embodiments disclosed herein relate to oral care compositions comprising zinc: lichenate complexes and methods of using and making these compositions. Background technique [0002] Many human diseases arise from pathogenic microorganisms, which include bacteria, viruses and fungi. The presence of such pathogenic microorganisms leads to sepsis, severe infections of the upper and lower respiratory tracts, severe infections of the central nervous system, meningitis, serious infections of intra-abdominal tissues including the peritoneum, genitourinary tract, skin and soft tissues, and various Other infections such as systemic mycoses, candidiasis, including those caused by skin fungi. Over the past 100 years, significant progress has been made in combating diseases caused by such a large family of microorganisms with a myriad of therapeutic agents of diverse chemical and biological properties that are already available as short- and long-term ...

Claims

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Application Information

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IPC IPC(8): A61K8/27A61K8/49A61Q11/00C07D307/91A61P1/02A61P31/02
CPCA61K8/27A61K8/4973C07D307/91A61K2800/58A61P1/02A61P31/02A61Q11/00A61K8/58C07F3/06
Inventor 斯坦尼斯拉夫·亚拉茨潘龙卡尔西克·桑班塔穆尔蒂
Owner COLGATE PALMOLIVE CO
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