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An optical coherence tomography method

A technology of optical coherence tomography and imaging method, which is applied in the directions of diagnosis, medical science, and diagnostic signal processing, etc. It can solve problems such as restricted application and slow speed, and achieve the effect of improving the depth of tomographic imaging and reducing the complexity

Active Publication Date: 2022-07-05
BEIJING INFORMATION SCI & TECH UNIV
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Problems solved by technology

However, since such technical solutions are all based on the time-domain OCT (TD-OCT) system, the measurement time for the two-dimensional transmission matrix of a single target layer generally takes about 6-7 minutes, which is very slow, which restricts its application in biological Applications in Tissue Imaging

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Embodiment Construction

[0047] In order to make the technical solutions and advantages of the present invention clearer, the present invention will be described in further detail below with reference to the accompanying drawings and specific embodiments.

[0048]The OCT system in the prior art usually uses an optical fiber (pinhole) as the medium at the signal receiving end. The detector records the interference echoes generated during the scanning process, and then generates two-dimensional or three-dimensional tomographic images according to the echo signals. Similar to the pinhole in a confocal microscope, the optical fiber receiving end of the OCT system in the prior art can filter out the optical echo from the area outside the focal area, and suppress the background echo and scattering noise from the non-focal area.

[0049] However, just like the physical phenomenon that a single stone stirs up a thousand layers of waves, the two-dimensional transverse light field distribution in the adjacent ar...

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Abstract

The invention provides an optical coherence tomography imaging method. The method includes: using a converged object beam to scan the sample point by point, and synchronously recording the interference signal of the wide-field backscattered light of each scanning point on the sample after interference with the reference light by an imaging device, so as to form a spectral interference image of each scanning point ; Perform fast Fourier transform on the spectral interference image of each scanning point to obtain the complex amplitude distribution of the light field corresponding to each scanning point; combine the complex amplitude distribution of the light field corresponding to each scanning point in the scanning order to form the back transmission of the scattering medium matrix; perform singular value decomposition on the back transmission matrix, extract the principal component signal from the matrix signal, and remove the multiple scattering noise signal; according to the extracted principal component signal, calculate the three-dimensional tomographic image at the focal plane of the object light. By applying the present invention, deep tissue imaging can be realized, and the imaging depth and imaging speed can be improved.

Description

technical field [0001] The present application relates to the technical field of optical imaging, and in particular, to an optical coherence tomography imaging method. Background technique [0002] Optical coherence tomography (OCT, Optical Coherence Tomography) technology uses the interference principle of a broad-spectrum light source to extract the layered information of the imaged tissue by detecting the interference signal between the backscattered light of the sample and the reference light. Because of its non-invasive, non-contact characteristics and tomographic imaging capabilities, OCT technology is widely used in ophthalmology, vascular endoscopy and other clinical medicine and pharmacology. [0003] Compared with the imaging depth of about 100 microns for confocal scanning microscopes and about 100 microns to 1 mm for two-photon microscopes, the imaging depth of traditional OCT systems in human soft tissues is about 1-2 mm. The imaging capabilities and micron-sca...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B3/10A61B3/12A61B3/14A61B5/00G01N21/45
CPCA61B3/102A61B3/1225A61B3/14A61B5/0066A61B5/72A61B5/7203G01N21/45
Inventor 杨强祝连庆朱疆樊凡端木正
Owner BEIJING INFORMATION SCI & TECH UNIV
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