Optical detection system adopting multi-lens switching structure

Abstract

The invention discloses an optical detection system adopting a multi-lens switching structure, and relates to a surface plasmon resonance optical detection system. The system mainly comprises an incident light unit, a reflected light unit and an objective table. The incident light unit and the reflected light unit are arranged in a bilateral symmetry mode; and change of an incident angle and a reflection angle is achieved through an angle sliding table or a rotary sliding table behind the incident light unit and the reflected light unit. According to the invention, the optical decomposition energy of SPR detection can be greatly improved, and the switching between various amplification power can be realized as required; micron-scale real-time surface plasmon resonance analysis and detection on a two-dimensional plane can be realized, and optical axis offset and aberration caused by angle change can be effectively corrected, so that detection errors can be reduced; and time variation ofreflectance at a specific angle may be used as a collection signal, and the specific angle may be set by calculating maximum difference of a resonance angle function curve of surface plasmon resonance. Therefore, the sensitivity is higher.

Description

technical field [0001] The invention relates to a surface plasmon resonance optical detection system, in particular to a two-dimensional micron-scale surface plasmon resonance optical detection system adopting a multi-lens switching structure. Background technique [0002] Currently, Surface Plasmon Resonance (SPR) is an optical physical phenomenon. Using SPR as an optical physical phenomenon can realize real-time observation of surface phenomena such as molecular binding and film formation, and can provide high-sensitivity and high-selectivity non-specific binding signals. In the current SPR detection instruments on the market, the prism coupling structure mostly adopts the Kretschmann structure. When the incident angle is greater than a certain value, the light emitted by the laser light source is totally reflected on the surface of the prism, and the light is irradiated to the optical sensitive device after the total reflection. The signal acquisition is completed. At p...

AI Technical Summary

Problems solved by technology

The offset between the optical axis and the imaging center will eventually lead to imaging shift, imaging deformation, imaging blur and imaging loss, which will eventually cause detection errors

The influence of the above-mentioned detection error increases with the improvement of the optical resolution

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