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Application of reef monostroma oligosaccharide and reef monostroma oligosaccharide derivative in colorectal cancer resistance

A sugar derivative, colorectal cancer technology, applied in the field of targeted COX-2 anti-colorectal cancer drugs and functional foods, to achieve the effects of easy industrialization, good market application prospects, and abundant resources

Active Publication Date: 2020-03-31
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, most of the literature reports are in the field of fucoidan polysaccharides and oligosaccharides. For green algae, because the results are more complicated, the research mainly focuses on the structure analysis and activity exploration of polysaccharides, and the research on oligosaccharides is rarely reported.

Method used

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  • Application of reef monostroma oligosaccharide and reef monostroma oligosaccharide derivative in colorectal cancer resistance
  • Application of reef monostroma oligosaccharide and reef monostroma oligosaccharide derivative in colorectal cancer resistance
  • Application of reef monostroma oligosaccharide and reef monostroma oligosaccharide derivative in colorectal cancer resistance

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preparation example Construction

[0044] Another embodiment of the present invention provides a method for preparing reef membrane oligobisaccharides, which specifically includes the following steps S1-S6:

[0045] S1, dissolving green algae in water to obtain a 5-15 wt% aqueous solution of green algae;

[0046] In this embodiment, the green algae is used as green alga reef algae powder, after dissolving the green algae reef algae powder in water, it is prepared into a 5-15 wt% aqueous solution of green algae reef algae.

[0047] S2. Add 1.0 wt% dilute sulfuric acid to the green algae aqueous solution, heat to 50-85° C., and stir to degrade the green algae chemically for 6-8 hours to obtain a degradation solution;

[0048]In this example, 1.0 wt% of dilute sulfuric acid is added to the aqueous solution of the green algae reef algae obtained in step S1, heated to 50-85° C., and stirred to chemically degrade the green algae reef algae for 6-8 hours , to obtain the degradation solution.

[0049] S3, placing the...

Embodiment 1

[0057] Embodiment 1 of the present invention provides a method for preparing reef membrane oligodisaccharides, which specifically includes the following steps S1-S6:

[0058] S1. After dissolving the green algae reef algae powder in water, prepare a 5wt% green algae reef algae aqueous solution.

[0059] S2. Add 1.0 wt% of dilute sulfuric acid to the aqueous solution of the green alga Reef algae obtained in step S1, heat to 50° C., and stir to chemically degrade the green alga Reef algae for 6 hours to obtain a degradation solution.

[0060] S3, placing the degradation solution obtained in step S2 in a dialysis bag for dialysis, and staying overnight to obtain a dialysis solution;

[0061] S4. Concentrating the dialysate obtained in step S3 with a rotator to obtain a primary concentrate, passing the obtained primary concentrate through a 1000Da ultrafiltration membrane to obtain oligosaccharides less than 1000Da;

[0062] S5. Concentrating the oligosaccharides obtained in step...

Embodiment 2

[0065] Embodiment 2 of the present invention provides a method for preparing reef membrane oligodisaccharides, which specifically includes the following steps S1-S6:

[0066] S1. After dissolving the green algae reef algae powder in water, prepare a 15wt% green algae reef algae aqueous solution.

[0067] S2. Add 1.0 wt% of dilute sulfuric acid to the aqueous solution of the green alga Reef algae obtained in step S1, heat to 85° C., and stir to chemically degrade the green algae Reef algae for 8 hours to obtain a degradation solution.

[0068] S3, placing the degradation solution obtained in step S2 in a dialysis bag for dialysis, and staying overnight to obtain a dialysis solution;

[0069] S4. Concentrating the dialysate obtained in step S3 with a rotator to obtain a primary concentrate, passing the obtained primary concentrate through a 1000Da ultrafiltration membrane to obtain oligosaccharides less than 1000Da;

[0070] S5. Concentrating the oligosaccharides obtained in st...

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Abstract

The embodiment of the invention provides application of reef monostroma oligosaccharide and a reef monostroma oligosaccharide derivative in colorectal cancer resistance. The reef monostroma oligosaccharide or the reef monostroma oligosaccharide derivative is used for treating the colorectal cancer. Specifically, the reef monostroma oligosaccharide or the reef monostroma oligosaccharide derivativeis applied to an anti-colorectal cancer drug, or the reef monostroma oligosaccharide or the reef monostroma oligosaccharide derivative is applied to an anti-colorectal cancer functional food. According to the embodiment of the invention, the enzyme activity of COX-2 is inhibited in a targeted manner and colon cancer cells are killed, so that the colorectal cancer is treated.

Description

technical field [0001] The invention belongs to the technical field of biotechnology drugs, and specifically relates to the application of reef membrane oligobisaccharides and reef membrane oligobisaccharide derivatives in anti-colorectal cancer, in particular to the application of reef membrane oligobisaccharides to target COX-2 anti-knot Rectal cancer drugs and functional foods, and the application of reef membrane oligobisaccharide derivatives to target COX-2 anti-colorectal cancer drugs and functional foods. Background technique [0002] In recent years, various malignant tumors have occurred frequently. Malignant tumors have always been a difficult point in the medical field. Among them, colorectal cancer, breast cancer, and lung cancer are more common. Therefore, the medical field has been devoting itself to conquering various malignant tumors. [0003] Taking colorectal cancer as an example, about 1.25 million people worldwide are diagnosed with colorectal cancer eac...

Claims

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Application Information

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IPC IPC(8): A61K31/7016A61P35/00A23L33/125A61K31/7024C07H3/04C07H1/06C07H11/00C07H11/04C07H13/04C13K13/00
CPCA61K31/7016A61P35/00A23L33/125A61K31/7024C07H3/04C07H1/06C07H11/00C07H11/04C07H13/04C13K13/00A23V2002/00A23V2200/308A23V2250/60
Inventor 程晓磊李新杨宁王馨瑶
Owner QINGDAO CENT HOSPITAL
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